PMID: 8448168Mar 2, 1993Paper

A possible family of B-like triple helix structures: comparison with the Arnott A-like triple helix

Biochemistry
M OualiE Taillandier

Abstract

Recent experimental studies of the structure of triple helices show that their conformation in solution differs from the A-like structure derived from diffraction data on triple helix fibers by Arnott and co-workers. Here we show by means of molecular modeling that a family of triple helix structures may exist with similar conformational energies, but with a variety of sugar puckers. The characteristics of these putative triple helices are analyzed for three different base sequences: (T.AxT)n, (C.GxC+)n, and alternating (C.GxC+/T.AxT)n. In the case of (C.GxC+)n triple helix, infrared and Raman spectra have been obtained and clearly reveal the existence of both N- and S-type sugars in solution. The molecular mechanics calculations allow us to propose a stereochemically reasonable model for this triple helix, in good agreement with the vibrational spectroscopy results.

Citations

Jun 1, 1995·Bioorganic & Medicinal Chemistry·E Tuite, B Nordén
Oct 1, 1993·Journal of Biomolecular Structure & Dynamics·C Y SekharuduM Sundaralingam
Dec 1, 1995·Journal of Biomolecular Structure & Dynamics·M R Kiran, M Bansal
Dec 1, 1996·Journal of Biomolecular Structure & Dynamics·F VovelleJ C Maurizot
Nov 25, 1993·Nucleic Acids Research·C H TungS Stein
Feb 13, 2001·Nucleic Acids Research·A K ShchyolkinaD J Arndt-Jovin
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·C EscudéC Hélène
Dec 5, 1994·FEBS Letters·R KlinckT Huynh-Dinh
May 1, 1995·Biopolymers·Y K Cheng, B M Pettitt
Sep 10, 2003·Chembiochem : a European Journal of Chemical Biology·Rula ZainJian-Sheng Sun
Aug 27, 2015·Journal of Biomolecular Structure & Dynamics·Anna K ShchyolkinaVictor B Zhurkin
Dec 24, 1998·Chemistry & Biology·T de BizemontC Hélène
Sep 20, 2001·Journal of the American Chemical Society·M P Teulade-FichouC Helene

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