A possible in vivo generator 103Pd/103mRh--recoil considerations

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Johann van RooyenJan Rijn Zeevaart

Abstract

The use of Auger emitters as potential radiopharmaceuticals is increasingly investigated. One such radionuclide of interest is (103m)Rh. This can be produced from (103)Ru or from (103)Pd in an in vivo generator. A potential problem with this concept is the recoil of the (103m)Rh out of the carrier molecule and even out of the target cell. In order to determine whether this would happen in the (103)Pd/(103m)Rh case calculations were done to prove that this does not happen. From theoretical considerations it seems that the (103)Pd/(103m)Rh in vivo generator system would be possible.

References

Jun 27, 2002·Current Urology Reports·Jerrold SharkeyRichard Rabinowitz
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Jan 12, 2007·European Journal of Nuclear Medicine and Molecular Imaging·J H McKillopA J Britten

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Citations

Mar 22, 2015·Nuclear Medicine and Biology·C AlliotS Huclier-Markai
Jan 7, 2017·Bioinorganic Chemistry and Applications·Patricia E EdemGregory Severin

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