A possible inhibitory action of diaminodiphenyl sulfone on tumour necrosis factor-alpha production from activated mononuclear cells on cutaneous lupus erythematosus

Clinical and Experimental Dermatology
M AbeO Ishikawa

Abstract

We have previously reported that diaminodiphenyl sulfone (DDS; dapsone) can bring about significant clinical improvement in patients with cutaneous lupus erythematosus (CLE). However, the pharmacological actions of DDS in the skin lesion of patients with CLE are still unknown. In this study, we aimed to clarify the pharmacological actions of DDS on CLE. We conducted an in vitro study to examine the effects of DDS on the mRNA expression and production of cytokines on lipopolysaccharide-stimulated peripheral blood mononuclear cells. Results. DDS suppressed mRNA expression of tumour necrosis factor (TNF)-alpha and significantly decreased the level of TNF-alpha in culture supernatant. DDS may exert an anti-inflammatory action by suppressing TNF-alpha produced by activated mononuclear cells.

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Citations

Dec 7, 2013·Archives of Dermatological Research·Gottfried Wozel, Christian Blasum
May 2, 2015·Neurochemical Research·Camilo RíosAraceli Diaz-Ruiz
Oct 18, 2019·Immunopharmacology and Immunotoxicology·Amir RashidianAhmad Reza Dehpour
Jan 10, 2020·Cancer Chemotherapy and Pharmacology·Mohammad SheibaniAhmad Reza Dehpour
Aug 23, 2020·International Journal of Molecular Sciences·Jong-Hoon LeeSangsuk Oh
Mar 7, 2021·Medical Sciences : Open Access Journal·Richard E Kast

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