PMID: 696293Jul 1, 1978Paper

A possible involvement of acidic glycosaminoglycans in kanamycin ototoxicity

Acta Oto-laryngologica
M TachibanaH Morioka

Abstract

The content of acidic glycosaminoglycans (AGAG) was determined quantitatively by electrophoretic microanalysis in the cochlea, kidney and brain of the guinea pig. Kanamycin treatment (400 mg/kg body weight/day, i.m., 10 successive days) reduced the content of AGAG markedly in the lateral wall of the membranous cochlea. Furthermore, from the results of the ultrahistochemical and freeze-fracturing study, we propose here an "excretion system for basic aminoglycoside antibiotics" by means of the co-operation of spiral ligament cells and AGAG produced by them. Thus we have tentatively concluded both that kanamycin is excreted via the above mentioned "excretion system" in the lateral wall of the membranous cochlea and that it damages this system to form the circulus vitiosus of its opopoxicity.

References

Nov 1, 1976·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·M TachibanaM Machino
Jul 1, 1973·Acta Oto-laryngologica·M TachibanaM Machino
Sep 1, 1956·Biochimica Et Biophysica Acta·E DAVIDSONK MEYER
Jan 1, 1961·Acta Oto-laryngologica. Supplementum·T VILSTRUP, C E JENSEN
Mar 1, 1960·Acta Oto-laryngologica·G DOHLMAN

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Citations

Jan 1, 1987·Hearing Research·P A Santi, C B Anderson
Jan 1, 1987·Auris, Nasus, Larynx·H SaitoS Shida
Mar 1, 1983·Journal of Clinical and Hospital Pharmacy·E J LienL L Lien
Mar 1, 1996·Acta Oto-laryngologica·M CigesA Campos
Mar 1, 1985·Acta Oto-laryngologica·N SitarasA Coyas

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