A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial

Pediatric Research
Anna PärttyErika Isolauri

Abstract

Recent experimental evidence suggests that gut microbiota may alter function within the nervous system providing new insight on the mechanism of neuropsychiatric disorders. Seventy-five infants who were randomized to receive Lactobacillus rhamnosus GG (ATCC 53103) or placebo during the first 6 mo of life were followed-up for 13 y. Gut microbiota was assessed at the age of 3 wk, 3, 6, 12, 18, 24 mo, and 13 y using fluorescein in situ hybridization (FISH) and qPCR, and indirectly by determining the blood group secretor type at the age of 13 y. The diagnoses of attention deficit hyperactivity disorder (ADHD) and Asperger syndrome (AS) by a child neurologist or psychiatrist were based on ICD-10 diagnostic criteria. At the age of 13 y, ADHD or AS was diagnosed in 6/35 (17.1%) children in the placebo and none in the probiotic group (P = 0.008). The mean (SD) numbers of Bifidobacterium species bacteria in feces during the first 6 mo of life was lower in affected children 8.26 (1.24) log cells/g than in healthy children 9.12 (0.64) log cells/g; P = 0.03. Probiotic supplementation early in life may reduce the risk of neuropsychiatric disorder development later in childhood possible by mechanisms not limited to gut microbiota composition.

References

Apr 1, 1988·Archives of Disease in Childhood·R G BarrI B Pless
Nov 9, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·S SprichS V Faraone
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·M KalliomäkiE Isolauri
Mar 22, 2001·Archives of Disease in Childhood·M KalliomäkiE Isolauri
Dec 26, 2001·JAMA : the Journal of the American Medical Association·G H Brundtland
Aug 10, 2002·JAMA : the Journal of the American Medical Association·Adnan T BhuttaK J S Anand
May 5, 2004·The British Journal of Psychiatry : the Journal of Mental Science·T B UstünC J L Murray
Apr 24, 2008·European Child & Adolescent Psychiatry·Lidy M J PelsserJan K Buitelaar
Jun 10, 2008·Current Pharmaceutical Design·E IsolauriS Salminen
Oct 10, 2008·The American Journal of Clinical Nutrition·Maria Carmen ColladoSeppo Salminen
Jun 2, 2009·Brain, Behavior, and Immunity·Paul ForsytheJohn Bienenstock
Aug 5, 2009·Pediatrics·Cornelieke Sandrine Hanan Aarnoudse-MoensJaap Oosterlaan
Aug 6, 2010·The American Journal of Psychiatry·Paul LichtensteinHenrik Anckarsäter
Sep 21, 2010·Journal of Microbiological Methods·Lotta NylundReetta Satokari
Oct 23, 2010·Gut·Mélanie G GareauPhilip M Sherman
Nov 9, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K M NeufeldJ A Foster
Nov 26, 2010·Neuroscience and Biobehavioral Reviews·Belinda A GargaroDianne M Sheppard
Feb 10, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J F Cryan, S M O'Mahony
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Javier A BravoJohn F Cryan
Sep 10, 2011·Archives of Disease in Childhood·Anita ThaparEvangelia Stergiakouli
Sep 29, 2011·Journal of Pediatric Gastroenterology and Nutrition·Deolinda M F ScalabrinJon A Vanderhoof
Oct 13, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P BercikE F Verdu
Oct 27, 2011·European Child & Adolescent Psychiatry·Katherine H SheltonAnita Thapar
Mar 12, 2013·Gastroenterology·Kirsten TillischEmeran A Mayer

❮ Previous
Next ❯

Citations

May 8, 2015·Journal of Physiological Anthropology·Alan C Logan
Apr 29, 2016·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Alan C LoganSusan L Prescott
Jul 14, 2016·Journal of Physiological Anthropology·Emily Deans
Oct 21, 2016·The Journal of Infection·Nicola Principi, Susanna Esposito
Oct 21, 2016·Journal of Translational Medicine·Giulia Umbrello, Susanna Esposito
Nov 7, 2016·The Lancet. Diabetes & Endocrinology·De-Kun LiRoxana Odouli
Nov 8, 2016·PloS One·Maria Del Mar Rigo-AdroverFrancisco José Pérez-Cano
Jan 11, 2017·The Australian and New Zealand Journal of Psychiatry·Amy R RomijnChris Frampton
Jul 16, 2016·Scientific Reports·Luca BorrelliAlessandro Fioretti
Mar 17, 2016·Food & Function·Ashkan HashemiElena M Comelli
Jul 13, 2018·PloS One·Alexander Prehn-KristensenAnnegret Fischer
Aug 14, 2018·The International Journal of Neuropsychopharmacology·Thomaz F S BastiaanssenJohn F Cryan
Sep 11, 2018·Beneficial Microbes·S SalvatoreY Vandenplas
Sep 5, 2018·Behavioural Pharmacology·Pablo RomanAlda Cortes-Rodríguez
Aug 2, 2017·Nutritional Neuroscience·Hande Cekici, Nevin Sanlier
Feb 10, 2018·Current Environmental Health Reports·Shannon Delaney, Mady Hornig
Nov 22, 2018·Developmental Psychobiology·Jing Lu, Erika C Claud
Jul 2, 2019·Expert Review of Neurotherapeutics·Luigi Francesco IannonePasquale Striano
Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
Jul 31, 2019·American Journal of Physiology. Endocrinology and Metabolism·Tomás CerdóCristina Campoy
Dec 27, 2019·Nutrition Reviews·Elisa KarhuAdrien A Eshraghi
Nov 21, 2019·Nutrients·Stephanie Bull-Larsen, M Hasan Mohajeri
Apr 14, 2020·Journal of Developmental Origins of Health and Disease·Amy LoughmanMimi L K Tang
Jul 22, 2019·Journal of Food and Drug Analysis·Li-Hao ChengYing-Chieh Tsai
Jun 24, 2019·Archives of Disease in Childhood·May Rivas-FernándezAlbert Balaguer
Jun 14, 2020·International Journal of Molecular Sciences·Basma AbdellatifAli Chaari
Dec 29, 2016·World Journal of Gastroenterology : WJG·Fernando NavarroJon Marc Rhoads
Jan 24, 2019·Developmental Psychobiology·Morgan R FiresteinMartha G Welch
Mar 3, 2019·Nutrients·Antonella FattorussoSusanna Esposito

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Asperger Syndrome

Asperger syndrome (AS), also known as Asperger's, is a developmental disorder characterized by significant difficulties in social interaction and nonverbal communication, along with restricted and repetitive patterns of behavior and interests. Discover the latest research on Asperger syndrome here.

Related Papers

Nestlé Nutrition Workshop Series. Paediatric Programme
Seppo Salminen, Miguel Gueimonde
Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association
N VendtR Korpela
Journal of Pediatric Gastroenterology and Nutrition
Miguel GueimondeSeppo Salminen
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Bo XinMing-Jing Situ
© 2021 Meta ULC. All rights reserved