A Possible Link of Genetic Variations in ER/IGF1R Pathway and Risk of Melanoma.

International Journal of Molecular Sciences
Tze-An YuanFeng Liu-Smith

Abstract

The mechanism of gender disparity in cutaneous melanoma incidence remains unclear. Steroid hormones including estrogens have long been implicated in the course of melanoma, but the conclusion is controversial. Estrogen receptors (ERs) and insulin-like growth factor 1 receptor (IGF1R) show extensive crosstalk in cancer development, but how the ER/IGF1R network impacts melanoma is currently unclear. Here we studied the melanoma associations of selected SNPs from the ER/IGF1R network. Part of the International Genes, Environment, and Melanoma (GEM) cohort was used as a discovery set, and the Gene Environment Association Studies Initiative (GENEVA) dataset served as a validation set. Based on the associations with other malignant disease conditions, thirteen single nucleotide polymorphism (SNP) variants in ESR1, ESR2, IGF1, and IGF1R were selected for candidate gene association analyses. The rs1520220 in IGF1 and rs2229765 in IGF1R variants were significantly associated with melanoma risk in the GEM dataset after Benjamini-Hochberg multiple comparison correction, although they were not validated in the GENEVA set. The discrepancy may be caused by the multiple melanoma characteristics in the GEM patients. Further analysis of gender ...Continue Reading

References

May 1, 1990·Annals of Surgery·C L SlingluffH F Seigler
Jun 1, 1982·International Journal of Epidemiology·J A Lee, B E Storer
Apr 6, 2000·The Journal of Biological Chemistry·S KahlertC Grohe
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·L D MarrettB K Armstrong
Apr 16, 2002·British Journal of Cancer·M R KaragasA J Swerdlow
Apr 19, 2003·Experimental Dermatology·M J ThorntonA G Messenger
Dec 18, 2004·Cancer Research·Bert GoldKenneth Offit
Jan 19, 2006·Journal of the National Cancer Institute·Iona ChengMatthew L Freedman
Mar 3, 2006·The Journal of Clinical Investigation·Bonnie J Deroo, Kenneth S Korach
Mar 25, 2006·International Journal of Epidemiology·Colin B BeggUNKNOWN GEM Study Group
Nov 7, 2006·Experimental Dermatology·Adriana N SchmidtDarrel L Ellis
Oct 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Mattias JohanssonRudolf Kaaks
Jan 10, 2008·International Journal of Cancer. Journal International Du Cancer·Chunying LiQingyi Wei
Oct 28, 2009·Carcinogenesis·Kathryn L TerrySusan E Hankinson
Jun 24, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shian-ling DingChen-Yang Shen
Jan 26, 2011·Journal of the National Cancer Institute·Olivia FletcherJulian Peto
Feb 5, 2011·Nature Protocols·Geraldine M ClarkeKrina T Zondervan
Mar 31, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jennifer Permuth-WeyThomas A Sellers
May 6, 2011·International Journal of Cancer. Journal International Du Cancer·Pedram RazaviGiske Ursin
May 31, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniSaverio Caini
Aug 17, 2011·Cancer Research·Kristen N StevensFergus J Couch
Nov 26, 2011·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Diego AlbaniGianluigi Forloni
Aug 17, 2012·BMC Public Health·Elizabeth M PooleHeather J Baer
Aug 23, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Se Hee ChoJoo-Ho Chung
Nov 7, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jana VranovaJozef Rosina
Nov 28, 2012·Journal of Cancer Research and Clinical Oncology·Axel MuendleinMichael Hubalek
Mar 29, 2013·Cancer Research·Kristen N StevensFergus J Couch
Apr 27, 2013·Cancer Epidemiology·Ji Young SongJoel L Weissfeld
May 25, 2013·PloS One·Zhenghong YuTangfeng Lv
Jul 9, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Merete Ellingjord-DaleGiske Ursin
Jul 30, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marianne BerwickColin B Begg
Sep 6, 2014·Molecular Biology Reports·Noyko S StanilovSpaska A Stanilova

❮ Previous
Next ❯

Citations

Jul 11, 2020·Cancers·Maria BellenghiGianfranco Mattia
Oct 12, 2021·Experimental and Therapeutic Medicine·Florica SandruAdina Ghemigian

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

RStudio
Plink

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.