A possible link of oxaliplatin-induced neuropathy with potassium channel deficit

Muscle & Nerve
Alexander G Dimitrov, Nonna A Dimitrova

Abstract

The neurotoxic side effects of oxaliplatin (a reference drug in the treatment of digestive tract tumors) can force suspension of treatment. The mechanisms of neuropathy are unclear. We aimed to simulate oxaliplatin-induced hyperactivity in myelinated axons (MA) based on published experimental data. A Hodgkin-Huxley-type multi-cable MA model was used, which took into account active internodal processes and accumulation of ions in MA with 21 nodes. Even a very short (110-220 μm) internodal region devoid of potassium channels was sufficient to produce after-discharges in response to a saltatory action potential. An increase in the density of sodium channels, slowdown of their inactivation, and negative shifts along one node-internode region of the voltage dependence of sodium and potassium activation and of sodium inactivation induced no after-discharge. A combination of sodium channel blockers with drugs that obstruct the blockage of potassium channels or contribute to their opening could be effective in preventing oxaliplatin-induced "hyperexcitability."

References

Feb 7, 1991·Journal of Theoretical Biology·J A Halter, J W Clark
Feb 12, 1998·Journal of Neuroscience Research·I VabnickP Shrager
Oct 20, 1998·Journal of Neurobiology·I Vabnick, P Shrager
Aug 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A de GramontA Bonetti
Sep 30, 2000·European Journal of Pharmacology·H AdelsbergerC Lersch
Aug 22, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·D BurkeH Bostock
Nov 17, 2001·British Journal of Cancer·M J McKeageB C Baguley
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard H WilsonJean L Grem
Aug 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Renate Schmelz, Christian Lersch
Nov 8, 2002·Seminars in Oncology·Jim Cassidy, Jean-Louis Misset
Oct 3, 2003·Seminars in Oncology·Axel Grothey
Jun 4, 2004·The New England Journal of Medicine·Thierry AndréUNKNOWN Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC)
Dec 14, 2004·The Annals of Pharmacotherapy·Robert J Cersosimo
May 6, 2005·Clinical Colorectal Cancer·Axel Grothey
May 10, 2005·Muscle & Nerve·Arun V KrishnanMatthew C Kiernan
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arun V KrishnanMatthew C Kiernan
May 18, 2007·CA: a Cancer Journal for Clinicians·Brian M WolpinRobert J Mayer
Mar 19, 2008·Journal of the Peripheral Nervous System : JPNS·Anthony J Windebank, Wolfgang Grisold
Jan 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susanna B ParkMatthew C Kiernan
Feb 12, 2009·Pflügers Archiv : European journal of physiology·Alexander G Dimitrov
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thierry AndréAimery de Gramont
Sep 12, 2009·Brain : a Journal of Neurology·Susanna B ParkMatthew C Kiernan
Jan 1, 2009·Oncology·Lucia LombardiEvaristo Maiello

❮ Previous
Next ❯

Citations

Dec 21, 2013·The Journal of Clinical Investigation·Romain CoriatFrédéric Batteux
Sep 3, 2013·Current Opinion in Neurology·Manuel DieziThierry Kuntzer
Dec 25, 2013·Clinical Colorectal Cancer·Ahmed Hussein ZedanOle Jakob Vilholm
May 19, 2012·European Journal of Cancer Care·J C McHughS Connolly
Apr 13, 2013·Muscle & Nerve·Alexander G Dimitrov, Nonna A Dimitrova
Jun 20, 2015·Pain Management·Jessica A Boyette-DavisPatrick M Dougherty
Jan 27, 2015·Neuroscience Letters·Christopher R Cashman, Ahmet Höke
Sep 14, 2013·Critical Reviews in Oncology/hematology·María SerenoEnrique Casado
May 23, 2019·Expert Opinion on Drug Metabolism & Toxicology·Paola Alberti
Sep 3, 2013·Current Pain and Headache Reports·Jérémy FerrierDavid Balayssac
Jun 11, 2020·Journal of Neurophysiology·Preet G S MakkerGila Moalem-Taylor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Gerardo Gutiérrez-GutiérrezEduardo Gutiérrez-Rivas
Expert Opinion on Pharmacotherapy
Jörg Thomas Hartmann, Hans-Peter Lipp
© 2022 Meta ULC. All rights reserved