A possible mechanism for alteration of human erectile function by digoxin: inhibition of corpus cavernosum sodium/potassium adenosine triphosphatase activity

The Journal of Urology
S GuptaI Goldstein

Abstract

Digoxin use has long been recognized to affect adversely male sexual function but the underlying mechanism is poorly understood. Digoxin is a known inhibitor of sodium/potassium adenosine triphosphatase (sodium pump), a plasma membrane enzyme that has a role in the regulation of smooth muscle tone. We investigated the effects of digoxin on human corpus cavernosum smooth muscle contractility and overall erectile function. In human corporeal smooth muscle strips the in vitro effects of digoxin were assessed on sodium pump activity as measured by digoxin inhibitable uptake of 86rubidium, basal tone and endothelium dependent, neurogenic and nitric oxide donor induced relaxation. An in vivo prospective double-blind, placebo controlled, crossover, 4-period investigation was performed in 6 healthy male volunteers. The effects of digoxin on serum hormones, erectile function questionnaire, visual sexual stimulation and nocturnal penile tumescence were recorded. In vitro digoxin caused concentration dependent inhibition of 86rubidium uptake (half maximum effect at 0.01 microM.) and contraction of corporeal smooth muscle (half maximum effect at 0.8 microM.). Therapeutic concentrations of digoxin (2 nM.) also inhibited relaxation induced b...Continue Reading

References

Mar 1, 1988·British Journal of Pharmacology·M Feletou, P M Vanhoutte
Dec 14, 1989·The New England Journal of Medicine·R J KraneI Saenz de Tejada
Apr 20, 1989·The New England Journal of Medicine·I Saenz de TejadaR A Cohen
Jan 1, 1987·Journal of Sex & Marital Therapy·A NeriH Kaufman
Jan 23, 1986·The New England Journal of Medicine·P J Hilton
May 1, 1988·Biological Psychiatry·M E ThaseD J Kupfer
Sep 1, 1988·Journal of Gerontology·R C Schiavi, P Schreiner-Engel
May 1, 1987·The Journal of Urology·T F Lue, E A Tanagho
Jul 1, 1982·Clinical Pharmacology and Therapeutics·H K KleyH L Krüskemper
Nov 1, 1984·Journal of Clinical Pharmacology·O BellmannD J Greenblatt
Feb 1, 1980·Urology·J D Francis
May 1, 1994·Journal of Clinical Epidemiology·H A FeldmanJ B McKinlay
Jun 1, 1993·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·G B Brock, T F Lue
Jul 7, 1993·JAMA : the Journal of the American Medical Association
Feb 20, 1997·The New England Journal of Medicine·UNKNOWN Digitalis Investigation Group

❮ Previous
Next ❯

Citations

Jul 29, 2010·Current Heart Failure Reports·Afshan BaraghoushErnst R Schwarz
Sep 30, 2010·Current Urology Reports·Adam ShrewsberryChad W M Ritenour
Apr 24, 2009·International Journal of Impotence Research·H Al-Ameri, R A Kloner
Sep 23, 2003·The Journal of Urology·Drogo K MontagueUNKNOWN Americal Urological Association
May 16, 2008·International Journal of Clinical Practice·A MuneerD J Ralph
Nov 8, 2011·Asian Journal of Andrology·Helen R LeveyTrinity J Bivalacqua
Oct 25, 2013·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M P J NicolaiH W Elzevier
Dec 10, 2013·European Urology·Andrea SaloniaUNKNOWN European Association of Urology
Dec 19, 2007·Asian Journal of Andrology·Jiuhong YuanRun Wang
May 9, 2009·Nature Reviews. Urology·Yun-Ching HuangTom F Lue
Mar 1, 2015·Sexual Medicine Reviews·Michael P Hoeh, Laurence A Levine
May 21, 2009·The Journal of Sexual Medicine·Damian DomanskiErnst R Schwarz
Jan 21, 2006·The Journal of Sexual Medicine·Rany Shamloul, Abdelrahman el Nashaar
Jul 21, 2009·Urology·Daibes Rachid-FilhoFrancisco J B Sampaio
Nov 7, 2007·The Urologic Clinics of North America·Arthur L Burnett, Trinity J Bivalacqua
Sep 3, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Shin-Ichi HisasueTaiji Tsukamoto
Sep 17, 2008·BJU International·Karyee Chow, Steve Payne
May 11, 2012·British Journal of Haematology·Ryan RodgersMhairi Copland
Sep 15, 2011·BJU International·Pejman KheirandishShailesh Kulkarni
Dec 28, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Robert Ritchie, Mark Sullivan
Jun 18, 2017·Andrology·M SemetJ Perrin
Dec 2, 2014·Therapeutic Advances in Urology·Helen R LeveyTrinity J Bivalacqua
Mar 16, 2011·Nature Reviews. Urology·Belinda F Morrison, Arthur L Burnett
Jun 12, 2002·International Journal of Impotence Research·U Simonsen
Jun 17, 2020·Andrologia·Ayodeji Folorunsho Ajayi, Roland Eghoghosoa Akhigbe
Sep 22, 2017·Therapeutic Advances in Urology·Georgios KousournasEvangelos Zacharakis
Oct 16, 2002·Vascular Pharmacology·Stephen L Archer
Aug 1, 2021·Nature Reviews. Cardiology·Dimitrios Terentes-PrintziosCharalambos Vlachopoulos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.