PMID: 9535488Apr 16, 1998Paper

A possible mechanism for electrocardiographically silent changes in cardiac repolarization

Journal of Electrocardiology
Rob S MacleodB Taccardi

Abstract

Despite the widespread use of electrocardiogram (ECG), changes in cardiac activity resulting from ischemia or altered recovery characteristics sometimes remain electrocardiographically "silent" or are first detectable by techniques that measure ventricular contractility, such as ultrasound or blood pressure. Especially local changes in repolarization can go undetected when ECG electrodes do not lie close to the area of the heart affected. Experiments were performed on an isolated, perfused canine heart suspended in a realistically shaped, instrumented, electrolytic torso tank with the goal of determining some mechanisms for these ambiguities. By recording simultaneously both epicardial and torso tank surface potentials, complete descriptions were obtained of the electrical response to interventions such as coronary occlusions and alterations in pacing site and frequency. One hypothesis was that some interventions produce highly variable ECG responses primarily because of differences in their location within the heart. To test this, the effect was measured of repeating the same intervention as the heart's location and orientation in the tank were varied. A numerical forward solution was also used to investigate variation of tors...Continue Reading

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Citations

Dec 12, 2012·Medical & Biological Engineering & Computing·Yesim Serinagaoglu Dogrusoz, Alireza Mazloumi Gavgani
Jun 28, 2005·IEEE Transactions on Bio-medical Engineering·Yeşim SerinagaogluRobert S MacLeod
Oct 6, 2006·IEEE Transactions on Bio-medical Engineering·Yeşim SerinagaogluRobert S MacLeod
May 4, 2011·IEEE Transactions on Bio-medical Engineering·David U J KellerGunnar Seemann
Apr 8, 2011·Medical & Biological Engineering & Computing·Umit Aydin, Yesim Serinagaoglu Dogrusoz
Sep 8, 2011·Physics in Medicine and Biology·Liansheng WangPheng Ann Heng
Jan 22, 2005·Pacing and Clinical Electrophysiology : PACE·Birgit HailerPeter Van Leeuwen
Mar 27, 2001·Journal of Electrocardiology·R S MacLeodB Taccardi

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