A possible mechanism for host-specific pathogenesis of Salmonella serovars

Microbial Pathogenesis
Y Ishibashi, T Arai

Abstract

We have identified the complement receptors on human and murine macrophages involved in the recognition of Salmonella serovars, and investigated their relevance to the intracellular survival. S. typhi was capable of surviving within human monocyte-derived macrophages, whereas S. typhimurium was not. Conversely, S. typhimurium, but not S. typhi, resisted intracellular killing by murine macrophages, demonstrating that the intracellular survival of Salmonella serovars is host-dependent. In the presence of serum opsonin, human monocyte-derived macrophages recognized S. typhi and S. typhimurium via complement receptor type 1 (CR1) and type 3 (CR3), respectively. In contrast, murine macrophages recognized S. typhi and S. typhimurium via CR3 and CR1, respectively. These findings demonstrate that the intracellular fate of Salmonella serovars following phagocytosis may depend on the type of complement receptors involved in their recognition, in that CR1-mediated recognition is closely correlated to subsequent intracellular survival. The Tn5 insertion mutant of S. typhimurium which lacks the ability to interact with CR1 was sensitive to intracellular killing by murine macrophages in vitro, and was much less virulent to mice in vivo, conf...Continue Reading

Citations

Jun 2, 2011·Infection and Immunity·Janet C LindowBeth D Kirkpatrick
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·R A EdwardsS R Maloy
May 20, 1998·Nature·G B PierW H Colledge
Nov 22, 2002·FEMS Immunology and Medical Microbiology·José Agramonte-HeviaMarco Velasco-Velázquez
Mar 22, 2007·Physiological Genomics·Wendy RodenburgJaap Keijer
Dec 3, 2010·Journal of Crohn's & Colitis·Renzo CaprilliArlette Darfeuille-Michaud
Oct 21, 1999·Canadian Journal of Microbiology·R S Negm, T G Pistole
Jan 29, 2020·FEBS Letters·Szilvia LukácsiAnna Erdei
Sep 24, 1998·Infection and Immunity·A J BäumlerL G Adams
Aug 8, 2009·Microbial Pathogenesis·Tong XuKathleen L McGuire

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