PMID: 16522979Mar 9, 2006Paper

A possible mechanism for phenol-induced pemphigus

Skinmed
S BrennerIlan Goldberg

Abstract

A possible mechanism for phenol-induced pemphigus lesions in genetically predisposed individuals is proposed that accounts for in vitro observations and cases of biochemical acantholysis, as well as the in vivo acantholysis in pemphigus induced by phenols. The mechanism involves the induction of interleukin-1a and tumor necrosis factor-a release by keratinocytes. These cytokines in turn have been shown to be involved in the regulation and synthesis of complement and proteases like plasminogen activator, which have been implicated in the pathogenesis of acantholysis in pemphigus vulgaris.

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Citations

Dec 6, 2011·Clinics in Dermatology·Suzana Ljubojevic, Jasna Lipozenčić
Nov 3, 2010·Clinics in Dermatology·Flavia FedelesJane M Grant-Kels
Dec 17, 2008·Clinical and Experimental Dermatology·A BaroniE Ruocco
Apr 4, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·A Lo SchiavoE Ruocco

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