PMID: 2114832Jan 1, 1990Paper

A possible mechanism of action for azelaic acid in the human epidermis

Archives of Dermatological Research
K U Schallreuter, J M Wood

Abstract

Azelaic acid, and other saturated dicarboxylic acids (C9-C12), are shown to be competitive inhibitors of tyrosinase (KI azelaic acid = 2.73 X 10(-3) M) and of membrane-associated thioredoxin reductase (KI azelaic acid = 1.25 X 10(-5) M). The monomethyl ester of azelaic acid does not inhibit thioredoxin reductase, but it does inhibit tyrosinase, although double the concentration is necessary compared with azelaic acid (KI azelaic acid monomethyl ester = 5.24 X 10(-3) M). Neither azelaic acid nor its monomethyl ester inhibit tyrosinase when catechol is used as a substrate instead of L-tyrosine. Therefore, the weak inhibitory action of azelaic acid on tyrosinase appears to be due to the competition of a single carboxylate group on this inhibitor for the alpha-carboxylate binding site of the L-tyrosine substrate on the enzyme active site. Based on the inhibitor constant on tyrosinase, at least cytotoxic levels of azelaic acid would be required for the direct inhibition of melanin biosynthesis in melanosomes if this mechanism is responsible for depigmentation in the hyperpigmentation disorders lentigo maligna and melasma. Alternatively only 10(-5) M azelaic acid is required to inhibit thioredoxin reductase. This enzyme is shown to r...Continue Reading

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Citations

Jun 15, 2010·Applied Biochemistry and Biotechnology·Yun-Ji GuoQing-Xi Chen
Sep 11, 2010·Journal of Biomedical Science·Ji Sun Yu, An Keun Kim
Sep 11, 2007·Biological & Pharmaceutical Bulletin·Young Mi HaHae Young Chung
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Dec 21, 2018·International Journal of Environmental Health Research·Mohamad Fawzi MahomoodallyMuhammad Zakariyyah Aumeeruddy
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Apr 11, 2020·Animal Reproduction Science·Erdogan MemiliAbdullah Kaya
Feb 20, 2003·Journal of Agricultural and Food Chemistry·Ohad NeryaSnait Tamir

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