A possible mechanism of action of 17 beta-estradiol in stimulation of fertilization in vitro

The Journal of Experimental Zoology
P Sjöblom, P E Lindahl

Abstract

The effects of 17 beta-estradiol (E2) on sperm-egg interactions in the mouse were investigated. It was shown that E2 induces adhesiveness of the sperm head, expressed as sperm-sperm and sperm-egg binding. Since the concentration dependence of this process was similar to that observed for stimulation of in vitro fertilization by E2, it is suggested that induction of adhesiveness or initiation of processes that cause adhesiveness of the sperm head are of biological significance as preparatory steps for fertilization. Finally, the content of E2 in mouse eggs was determined and found to be 0.2 pg/egg, equally distributed between the oocyte together with the zona pellucida and the follicular cells with their associated intercellular matrix. The intra-ovum concentration is estimated as 10(-6) M.

References

May 1, 1978·Experimental Cell Research·P E Lindahl
Aug 1, 1978·Developmental Biology·P M SalingD P Wolf
Jan 1, 1979·Archives of Andrology·O Hernández-PérezA Rosado
Jan 1, 1978·Journal of Reproduction and Fertility·P E LindahlP Sjöblom
Mar 1, 1985·Journal of Steroid Biochemistry·C M BergaminiG Mollica
Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·C M Szego, J S Davis
Feb 5, 1973·Biochemical and Biophysical Research Communications·B Morton, L Albagli
Apr 1, 1972·Journal of Reproduction and Fertility·A Pavlok, A McLaren
Aug 1, 1972·Journal of Reproduction and Fertility·H Miyamoto, M C Chang
Dec 1, 1970·Biology of Reproduction·P C Cross, R L Brinster
Nov 1, 1967·Acta Endocrinologica·R J EricssonD A Buthala
Feb 1, 1980·The Journal of Experimental Zoology·R J Mrsny, S Meizel
Aug 1, 1981·Biology of Reproduction·P E Lindahl, P Sjöblom
Jan 1, 1983·Journal of Reproduction and Fertility·J L DacheuxY Combarnous
Feb 1, 1982·The Journal of Experimental Zoology·L J Heffner, B T Storey
Jun 1, 1981·International Journal of Andrology·C Y ChengB Boettcher
Jan 1, 1981·Experientia·P E LindahlO Tottmar

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