A possible pre-zollinger-ellison state: report on a novel lesion.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
E A KollerD C Metz

Abstract

To describe a patient with a potential harbinger of Zollinger-Ellison syndrome. We present a case of a 29-year-old woman with persistent galactorrhea and gastric distress, who was a member of an extensive multiple endocrine neoplasia (MEN) I kindred. Both clinical and laboratory findings are reviewed. Laboratory studies were notable for persistent hypercalcemia and increased levels of parathyroid hormone and fasting pancreatic polypeptide. Because of nonspecific upper gastrointestinal distress, which was sometimes responsive to antacids, the patient underwent further diagnostic evaluation. Baseline gastrin levels were normal. A secretin challenge test yielded normal results. At upper endoscopy, visual findings in the stomach and duodenum were unremarkable. A raised nodule (4 by 2 by 2 mm) was removed from an otherwise normal-appearing duodenum as a routine biopsy procedure. The acinar architecture, the inconspicuous nucleoli, and the granular, eosinophilic cytoplasm of the cells were diagnostic of a neuroendocrine tumor. Histologic immunohistochemical staining was positive for gastrin but negative for pancreatic polypeptide. RNA studies were not technically possible. Subsequently, serum pancreatic polypeptide levels normalized....Continue Reading

References

Nov 1, 1992·Gastrointestinal Endoscopy·E StrausR T Jensen
Jan 1, 1989·Acta Oncologica·B ErikssonE Wilander
Apr 1, 1988·Pathology, Research and Practice·G Klöppel, P U Heitz
Nov 1, 1986·Gastroenterology·J C BartonR T Jensen
Nov 1, 1982·The Journal of Clinical Endocrinology and Metabolism·C B LamersJ J Peetoom
Jan 1, 1983·Annals of Internal Medicine·R T JensenM J Collen
Jan 1, 1984·American Journal of Surgery·B E StabileE Passaro

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Citations

Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·K Martin HoffmannRobert T Jensen

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