A possible relation of the Helicobacter pylori pfr gene to iron deficiency anemia?

Helicobacter
Y H ChoeM S Choi

Abstract

H. pylori infection is thought to contribute to iron-deficiency anemia, especially during puberty. The ferritin protein Pfr of H. pylori is homologous to eukaryotic and prokaryotic ferritins. The purpose of this study was to analyze the H. pylori pfr status in gastric biopsy specimens according to clinical data, including antral gastritis with or without iron-deficiency anemia. A total of 26 H. pylori-positive patients aged from 10-18 years were categorized into subgroups based on the presence or absence of iron-deficiency anemia. All of them had antral gastritis. Sixteen patients were proved to have iron-deficiency anemia by hematological study, two of which had a duodenal ulcer. The other 10 patients showed normal hematological findings. DNA isolation was performed from each of the gastric biopsy specimens. PCR amplification of the pfr gene coding was done using two sets of primers. The pfr region, 501 bp, was generated by linking the sequences of the two PCR products. The nucleotide and protein sequences were compared between the pfr regions from Korean H. pylori strains and the NCTC 11638 strain, which was obtained from the Genbank. Sequence comparisons were also performed for the pfr regions between the iron-deficiency ane...Continue Reading

References

Jan 1, 1994·Advances in Experimental Medicine and Biology·E I StiefelG D Watt
Aug 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·C DufourA Barabino
Jun 1, 1993·Infection and Immunity·M O HussonH Leclerc
Mar 26, 1997·JAMA : the Journal of the American Medical Association·A C LookerC L Johnson
Jun 1, 1997·Scandinavian Journal of Gastroenterology·M MarignaniB Annibale
Jul 1, 1997·Scandinavian Journal of Gastroenterology·O GutierrezD Y Graham
Jan 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·A BarabinoA De Alessandri
Jan 29, 2000·Archives of Disease in Childhood·Y H ChoeY C Hong

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Citations

Jan 6, 2004·International Journal of Hematology·Giovanna Russo-MancusoMilena La Spina
Mar 2, 2005·Best Practice & Research. Clinical Haematology·Chaim HershkoDan Kereth
Nov 1, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B AnnibaleG Delle Fave
Apr 23, 2002·Helicobacter·Arrigo Barabino
Nov 18, 2008·Journal of Paediatrics and Child Health·Michael CardamoneMark R Oliver
Jun 18, 2002·Infection and Immunity·Barbara WaidnerStefan Bereswill
Sep 30, 2009·World Journal of Gastroenterology : WJG·Fernando Fernández-BañaresMontserrat Forné
Jan 5, 2011·La Presse médicale·Nabil Ben ChaabaneHamouda Saffar
Aug 3, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C CiacciG Mazzacca
Jan 26, 2005·The American Journal of Gastroenterology·Suja DuBois, David J Kearney

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