PMID: 3773512Sep 1, 1986Paper

A possible role for endogenous glucocorticoids in orchiectomy-induced atrophy of the rat levator ani muscle: studies with RU 38486, a potent and selective antiglucocorticoid

Journal of Steroid Biochemistry
M Konagaya, S R Max

Abstract

We employed RU 38486, a potent and selective antiglucocorticoid, to study a possible role for endogenous glucocorticoids in atrophy of the levator ani muscle secondary to castration of male rats. RU 38486 was shown to block [3H]triamcinolone acetonide binding to cytosol from levator ani muscle. Daily oral administration of RU 38486 to castrated rats partially prevented atrophy of the levator ani muscle, as well as a decrease in RNA concentration. In a control group receiving RU 38486 alone, the levator ani underwent significant (20%) hypertrophy. Administration of exogenous dexamethasone also caused pronounced atrophy of the levator ani muscle. This atrophy was prevented, to a significant degree, by simultaneous oral administration of RU 38486. It is concluded that endogenous glucocorticoids, the actions of which are blocked by RU 38486, may be involved in regulation of the mass of the levator ani muscle in intact rats.

References

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Dec 1, 1974·Experimental Neurology·D H RifenberickS R Max
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Sep 1, 1981·Muscle & Nerve·D C DuBois, R R Almon

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Citations

Jun 1, 1987·Journal of the Neurological Sciences·M KonagayaS R Max
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Shalender BhasinThomas W Storer
Dec 20, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shalender BhasinNestor F Gonzalez-Cadavid
Feb 9, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Tianshun XuBajin Han
Nov 1, 1993·Contraception·I M Spitz, C W Bardin
Jun 15, 1987·FEBS Letters·M K AgarwalG Lazer
Sep 1, 1989·The American Journal of the Medical Sciences·S KawaiG P Chrousos
Nov 1, 1994·Metabolism: Clinical and Experimental·M E Tischler
Dec 12, 2003·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·M Sue MartyEdward W Carney
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·T TamakiV R Edgerton
May 2, 2003·American Journal of Physiology. Endocrinology and Metabolism·Kun MaBehrouz Salehian

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