A possible role for imprinted genes in inbreeding avoidance and dispersal from the natal area in mice

Proceedings. Biological Sciences
Anthony R IslesN D Allen

Abstract

The expression of a subset of mammalian genes is subject to parent of origin effects (POE), most of which can be explained by genomic imprinting. Analysis of mutant animals has demonstrated that a number of imprinted genes influence brain development and behaviour. Here we provide evidence for POE on olfactory related behaviour and sensitivity to maternal odour cues. This was investigated by examining the odour preference behaviour of reciprocal cross F(1) mice made by embryo transfer to genetically unrelated foster parents. We determined that both adult males and females show an avoidance of female urinary odours of their genetic maternal but not paternal origin. This was found not to be due to any previous exposure to these odours or due to self-learning, but may be related to direct effects on the olfactory system, as reciprocal F(1) males show differential sensitivity to female odour cues. Currently the most robust theory to explain the evolution of imprinting is the conflict hypothesis that focuses on maternal resource allocation to the developing foetus. Kinship considerations are also likely to be important in the selection of imprinted genes and we discuss our findings within this context, suggesting that imprinted gene...Continue Reading

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Citations

Oct 10, 2008·Molecular Biology and Evolution·Samir WadhawanAnton Nekrutenko
Nov 23, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anthony R IslesLawrence S Wilkinson
Mar 31, 2005·Molecular and Cellular Biology·Antonius PlaggeGavin Kelsey
Jan 22, 2008·Frontiers in Neuroendocrinology·William DaviesLawrence S Wilkinson
Aug 19, 2015·Annals of the New York Academy of Sciences·Andrew I FurnessDavid N Reznick
Aug 2, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·James P Curley
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Feb 15, 2005·Early Human Development·Anthony R Isles, Anthony J Holland
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Apr 1, 2006·Cytogenetic and Genome Research·A Plagge, G Kelsey
May 9, 2019·Proceedings. Biological Sciences·Aurelio F MaloPhilip Riordan
Jul 28, 2017·Frontiers in Zoology·Miriam Linnenbrink, Sophie von Merten
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jon F Wilkins, Tanmoy Bhattacharya

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