PMID: 8614237Mar 3, 1995Paper

A possible role for nitric oxide but not for prostaglandin E2 in basal and interleukin-1-beta-induced PRL release in vitro

Life Sciences
L BrunettiM Vacca

Abstract

In previous experiments we have shown that nitric oxide (NO) was able to modulate CRH and ACTH release from cultured rat hypothalamic and anterior pituitary cells, in vitro. Now, we show experimental evidence of an involvement of NO in basal and interleukin-1 beta-induced prolactin (PRL) release. L-NG-nitro-arginine, an inhibitor of nitric oxide synthetase, and hemoglobin, a NO scavenger, impaired basal and interleukin-1-beta-induced PRL release, while molsidomine, a NO donor, was able to release PRL and to amplify interleukin-1-beta-induced PRL release, confirming a modulatory role for nitric oxide in pituitary hormone secretion. On the other hand, no evidence regarding a possible role of prostaglandin E2 (PGE2) in IL-1beta-induced PRL release came out from our experiments.

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·V RettoriS M McCann
Nov 1, 1993·Cytokine·T H Jones, R L Kennedy

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Citations

Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anderson Luras, Keico O Nonaka
Jan 1, 1997·Brain Research Bulletin·S Ceccatelli
Dec 1, 1996·Journal of Neuroendocrinology·B H DuvilanskiA Seilicovich
Mar 31, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Jill M RussellP Callahan
Dec 2, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T González-Hernández, M C González
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
Sep 21, 2006·The Biochemical Journal·Tao SongYasuo Watanabe

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