A possible role for progesterone metabolites in human parturition

The Australian & New Zealand Journal of Obstetrics & Gynaecology
Penelope M Sheehan

Abstract

There has been a recent resurgence of interest in the role of progesterone in the maintenance of human pregnancy and the onset of labour, following recent reports of its use to prevent preterm labour in high-risk patients. One possible mechanism by which progesterone might contribute to uterine quiescence is through the actions of its metabolites. This article provides a brief overview of progesterone in human pregnancy and an outline of progesterone metabolism in the various reproductive tract tissues as well as the evidence for actions of progesterone metabolites in pregnancy.

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Citations

Sep 3, 2013·Biological & Pharmaceutical Bulletin·Satoshi EndoToshiyuki Matsunaga
Feb 12, 2014·Steroids·Mo Chen, Trevor M Penning
Jun 29, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Martin HillLuboslav Stárka
Mar 2, 2013·American Journal of Reproductive Immunology : AJRI·Elizabeth A Bonney
May 6, 2008·American Journal of Obstetrics and Gynecology·Ramsi HaddadHans H Zingg
Nov 10, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Martin HillLuboslav Stárka
Apr 16, 2019·Medical Education Online·Mustafa Kemal AlimogluLevent Ozgonul
Dec 1, 2010·Physiological Research·M HillJ E Jirásek

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