A Possible Role for Singlet Oxygen in the Degradation of Various Antioxidants. A Meta-Analysis and Review of Literature Data

Antioxidants
Athinoula L PetrouAntonis Liapis

Abstract

The thermodynamic parameters Eact, ΔH≠, ΔS≠, and ΔG≠for various processes involving antioxidants were calculated using literature kinetic data (k, T). The ΔG≠values of the antioxidants' processes vary in the range 91.27-116.46 kJmol-1at 310 K. The similarity of the ΔG≠values (for all of the antioxidants studied) is supported to be an indication that a common mechanism in the above antioxidant processes may be taking place. A value of about 10-30 kJmol-1is the activation energy for the diffusion of reactants depending on the reaction and the medium. The energy 92 kJmol-1is needed for the excitation of O₂ from the ground to the first excited state (¹Δg, singlet oxygen). We suggest the same role of the oxidative stress and specifically of singlet oxygen to the processes of antioxidants as in the processes of proteinaceous diseases. We therefore suggest a competition between the various antioxidants and the proteins of proteinaceous diseases in capturing singlet oxygen's empty π* orbital. The concentration of the antioxidants could be a crucial factor for the competition. Also, the structures of the antioxidant molecules play a significant role since the various structures have a different number of regions of high electron density.

References

Mar 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·R M Tyrrell, S M Keyse
Jan 1, 1989·Critical Reviews in Food Science and Nutrition·F J Francis
Jan 1, 1988·Neurobiology of Aging·A D Mooradian
May 1, 1987·Journal of Neurochemistry·I TayaraniJ M Bourre
Dec 24, 1971·Science·S V Amonkar, A Banerji
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Jan 1, 1983·Advances in Experimental Medicine and Biology·T J DoughertyK E Wityk
Jan 1, 1994·Life Sciences·C PieriF Marcheselli
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangP Talalay
Apr 22, 1994·Science·W C Willett
Aug 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·C TournaireE Oliveros
Jan 1, 1997·Nutrition Reviews·B Halliwell
Jun 20, 1998·JAMA : the Journal of the American Medical Association·H K BertholdK von Bergmann
Nov 18, 1998·Archives of Internal Medicine·N H MashourW H Frishman
Sep 29, 1999·Medical Physics·D A BellnierA R Oseroff
Dec 14, 1999·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·D ZieglerF A Gries
Apr 25, 2000·Journal of Agricultural and Food Chemistry·Y M Naguib
May 2, 2000·Applied and Environmental Microbiology·E A O'GaraD J Maslin
May 4, 2000·Progress in Lipid Research·X Wang, P J Quinn
Jul 19, 2000·Biological Signals and Receptors·D X TanJ R Calvo
Jan 12, 2001·Vitamins and Hormones·N Smirnoff
Feb 13, 2001·The Journal of Nutrition·L PackerG Rimbach
Feb 24, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P AvatoV Candido
Mar 10, 2001·The Journal of Nutrition·E J StabaJ E Staba
Mar 27, 2001·Archives of Internal Medicine·R T AckermannV A Lawrence
Aug 25, 2001·Journal of Physiology and Biochemistry·E Herrera, C Barbas
Jan 10, 2002·Journal of Agricultural and Food Chemistry·Chih-Chung WuChong-Kuei Lii
Jul 24, 2002·Nutrition in Clinical Care : an Official Publication of Tufts University·Elizabeth J Johnson
Feb 6, 2003·Journal of the American College of Nutrition·Sebastian J PadayattyMark Levine
Feb 26, 2003·Phytotherapy Research : PTR·S K BanerjeeS K Maulik
Oct 14, 2003·Biochemical Pharmacology·Alfonso PompellaAlessandro F Casini
Jan 27, 2004·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·E GermainC Teyssier
Mar 17, 2004·Free Radical Biology & Medicine·Robert J WilliamsCatherine Rice-Evans
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T FukaoT Ariga
May 12, 2004·Current Medicinal Chemistry·Jean-Marc Zingg, Angelo Azzi
Jun 23, 2004·Neurobiology of Disease·Praveen BallabhMaiken Nedergaard
Jan 11, 2005·The American Journal of Clinical Nutrition·Ilja C W Arts, Peter C H Hollman
Jan 11, 2005·The American Journal of Clinical Nutrition·Louise I MennenAugustin Scalbert
Feb 16, 2005·Brain Research. Molecular Brain Research·Seong-Ho KohSeung Hyun Kim
Aug 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Diana M BautistaPeter M Zygmunt
Oct 13, 2005·The International Journal of Biochemistry & Cell Biology·Rüdiger HardelandDaniel P Cardinali

❮ Previous
Next ❯

Citations

Dec 17, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Jomana Al-Nu'airatBogdan Z Dlugogorski
Jan 16, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luna KrstićYolanda Diebold
Mar 12, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Sakthi Jothi Muthu, Prakash Seppan
Mar 23, 2021·Biochemistry and Biophysics Reports·Tomoaki ShigetaTetsuro Yamamoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.