A possible role for the adenylcyclase system in insulin secretion

The Journal of Clinical Investigation
W J MalaisseD Mayhew

Abstract

A possible role for adenylcyclase in insulin secretion was investigated. Isoproterenol, a predominantly beta-adrenergic agent, when mixed with an alpha-adrenergic blocking agent (phenoxybenzamine), stimulated insulin secretion from pieces of the rat's pancreas in vitro. Theophylline, caffeine, 3'5'-cyclic AMP, glucagon, adrenocorticotropin (ACTH), and thyrotropin (TSH), all of which are thought to act through the adenylcyclase systems in the liver and adipose tissue, also stimulated insulin secretion in vitro; oxytocin and vasopressin, which do not stimulate lipolysis in adipose tissue, were inactive. In all cases, stimulation of insulin secretion could not be detected when glucose was absent or present in only low concentrations (less than 100 mg/100 ml) and was maximal at high levels of glucose (300 mg/100 ml). When pancreatic tissue was obtained from normoglycemic rats and contained no detectable glycogen in the Islets, the stimulant effects of glucose and of theophylline were reduced or abolished by mannoheptulose and 2-deoxyglucose. When tissue was derived from rats infused for 8-10 hr with glucose and contained glycogen, theophylline, even in the absence of glucose, stimulated secretion and this effect was reduced by 2-de...Continue Reading

References

Dec 3, 1966·Lancet·S Devrim, L Recant
Aug 1, 1967·Endocrinology·P H WrightI J Reynolds
Feb 1, 1966·Metabolism: Clinical and Experimental·P M CrockfordR H Williams
Feb 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·W J MalaisseP H Wright
Feb 1, 1966·The Journal of Clinical Investigation·D PorteR H Williams
Nov 1, 1966·Diabetologia·P H Wright, W J Malaisse
Aug 28, 1965·Lancet·E SAMOLSV MARKS

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Citations

Sep 1, 1994·Diabetologia·W J Malaisse
Apr 1, 1970·Diabetologia·A J MoodyF Sundby
Oct 1, 1969·Diabetologia·W Malaisse, F Malaisse-Lagae
Dec 19, 1975·European Journal of Clinical Pharmacology·G LentiA Diana
Dec 1, 1968·Diabetologia·W MalaisseS King
Aug 1, 1971·Diabetologia·B Jeanrenaud
Nov 1, 1974·Diabetologia·D P CameronS Insch
Jan 1, 1972·Acta diabetologica latina·H J Hahn, R Michael
Sep 1, 1977·Zeitschrift für Ernährungswissenschaft·T H Mikhail, R Awadallah
Oct 15, 1968·Experientia·J J GagliardinoR R Rodriguez
Jul 1, 1981·Molecular and Cellular Biochemistry·W J MalaisseF Malaisse-Lagae
Aug 1, 1969·European Journal of Pharmacology·I I Tabachnick, A Gulbenkian
Jan 1, 1970·European Journal of Pharmacology·W Malaisse, F Malaisse-Lagae
Nov 10, 1986·Life Sciences·M D MeglassonF M Matschinsky
Feb 1, 1972·Metabolism: Clinical and Experimental·G S LeveyD H Mintz
Jan 1, 1973·Progress in Biophysics and Molecular Biology·M W Bitensky, R E Gorman
Feb 1, 1981·Pharmacology, Biochemistry, and Behavior·A D MerkelR Mintz
Mar 1, 1985·Peptides·M D Hirsch, T L O'Donohue
Mar 1, 1974·Comparative Biochemistry and Physiology. A, Comparative Physiology·W B Rhoten
Feb 1, 1976·Molecular and Cellular Endocrinology·U K Schubart, O M Rosen
Aug 30, 1995·Molecular and Cellular Endocrinology·S G Laychock

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