PMID: 11341105May 9, 2001Paper

A possible role of apoptosis for regulating autoreactive responses in systemic lupus erythematosus

Lupus
M FunauchiA Kanamaru

Abstract

It has been reported that apoptotic cells are increased in the peripheral blood from patients with systemic lupus erythematosus (SLE), where dysfunctions of T helper 1 (Th1) cells are known. In order to study whether apoptosis of Th1 cells is associated with the pathogenesis of SLE, early apoptotic cells in various T-cell subsets were detected using fluorescence-labeled annexin V (AnV). AnV binding was most frequently observed in CD4+CCR5+ T cells, and AnV binding rate (%) in this subset was higher in SLE than in normal controls (14.7 +/- 2.6), although that in active SLE (43.6 +/- 7.3) tended to be lower than that in inactive SLE (48.0 +/- 6.8). CD95/Fas expression was also increased in both active and inactive SLE. In some SLE patients, AnV binding rate changed in inverse proportion to titer of the serum anti-DNA antibody and in proportion to serum complement activity. These data suggest that apoptosis in Th1 cells is important in the pathogenesis of SLE and might play a role in regulating over-activation or autoreactive responses by T cells.

References

Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Oct 1, 1994·Clinical Immunology and Immunopathology·S OhsakoS Kashiwazaki
Jun 1, 1995·Current Opinion in Immunology·J H Russell
Jun 1, 1994·Current Opinion in Immunology·D R Green, D W Scott
May 1, 1994·Journal of Clinical Immunology·B L BermasG M Shearer
Feb 5, 1998·Nature·P LoetscherJ M Dayer
Apr 18, 2000·Rheumatic Diseases Clinics of North America·F AndradeA Rosen

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Citations

Aug 13, 2011·Clinical Rheumatology·Maryam RastinMahmoud Mahmoudi
Feb 28, 2003·Clinical and Experimental Immunology·H AhsanR Ali
Dec 24, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Peter SzodorayRoland Jonsson
Jun 3, 2004·Physiological Genomics·Jiang LiJeffrey A Johnson

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis