PMID: 7010960Jan 1, 1981Paper

A possible role of iron deficiency in gastric cancer in Colombia

Advances in Experimental Medicine and Biology
S A BroitmanJ J Vitale

Abstract

Through the efforts of Correa, Cuello, Haenszel, Tannenbaum and others it was learned that the incidence of gastric cancer in certain areas of Narino (Colombia) was among the highest in the world. These areas of high risk for gastric cancer were adjacent to an area of substantially lower risk. Gastric biopsies from healthy volunteers residing in the "high risk" area exhibited a greater incidence of superficial gastritis and chronic atrophic gastritis with and without intestinal metaplasia than those from the low risk area. The latter pathological finding is considered to be a precursor lesion to gastric cancer. Volunteers from the "low risk" area as well as individuals from Cali in the coastal region and Cartegena on the coast, also exhibited a similar spectrum of pathology but at a substantially reduced frequency. Natives of both cities were also at lower risk for gastric cancer than inhabitants of Narino. It was found that the water supply of the "high risk" area contained a higher concentration of nitrate than water in the "low risk" area. Correa et al. hypothesized that the high nitrate concentrations of well water contributed to the formation of N-nitroso compounds in the stomachs of these individuals early in life. The oc...Continue Reading

Citations

Jan 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Koichiro TsuchiyaToshiaki Tamaki
Jan 1, 1990·Medical Oncology and Tumor Pharmacotherapy·R G Stevens

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