PMID: 9535053Apr 16, 1998Paper

A possible role of the pineal gland in acute immobilization-related suppression of naloxone-induced LH release in ovariectomized estrogen-primed rats

Journal of Neuroendocrinology
A ChibaJ Toyoda

Abstract

It has been recently reported that acute immobilization stress almost completely suppresses the luteinizing hormone (LH) release induced by naloxone, a mu-opioid antagonist, in ovariectomized estrogen-primed rats. The present study examined the possible involvement of the pineal gland in the acute immobilization-related suppression of the naloxone-induced LH release. An intraventricular (ICV) injection of 15 microg naloxone produced an abrupt increase in circulating LH concentrations in non-stressed rats. The naloxone-induced LH release was completely eliminated when tested 60 min after the end of a 30 min session of acute immobilization. The same stress conditions did not affect LH-releasing hormone (LHRH)-induced LH release, suggesting that the stress-related suppression of the naloxone-induced LH release was a suprapituitary event. In chronically-pinealectomized rats, but not in sham-pinealectomized rats, naloxone injected 60 min after the end of the stress session evoked a significant increase in serum LH concentrations. However, naloxone injected ICV during the acute immobilization did not elicit LH release in either pinealectomized or sham-operated rats. Under non-stressed conditions, the LH secretory response to naloxone...Continue Reading

References

Mar 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·C A Blake
Feb 1, 1990·The Journal of Endocrinology·A López-CalderónC Ariznavarreta
Jan 1, 1985·Journal of Pineal Research·G M VaughanA D Mason
Jan 1, 1973·Endocrinology·S Y Ying, R O Greep
Apr 1, 1984·The Journal of Endocrinology·F PetragliaE E Müller
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·K KawashimaS Spector
Nov 1, 1982·Journal of Reproduction and Fertility·G HulseK Greenwood
Jan 1, 1982·Neuroendocrinology·R F WalkerP S Timiras

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