A post hoc comparison of paroxetine and nortriptyline for symptoms of traumatic grief

The Journal of Clinical Psychiatry
M ZygmontC F Reynolds

Abstract

This report presents the results of an open-trial pilot study of paroxetine for symptoms of traumatic grief, compared with the effects of nortriptyline in an archival contrast group. Data are presented on 15 subjects (4 men, 11 women), ranging in age from 40 to 79 years (mean age = 57 years), who experienced the loss of a spouse (N = 8), child (N =5), grandchild (N = 1), or parent (N = 1). Subjects were required to have a baseline score on the Inventory of Complicated Grief (ICG) of > or = 20. Treatment with paroxetine began at a median of 17 months (range, 6-139 months) after the loss. Paroxetine-treated subjects received a psychotherapy tailored for traumatic grief. Depressive symptoms were assessed by using the Hamilton Rating Scale for Depression (HAM-D). The ICG and the HAM-D were administered weekly over 4 months of paroxetine treatment (median dose = 30 mg/day). The group receiving paroxetine were then compared with a group (N = 22) participating in a separate trial of nortriptyline (median dose = 77.5 mg/day) for treatment of bereavement-related major depressive episodes. Level of traumatic grief symptoms (ICG) decreased by 53%, and depression ratings (HAM-D) decreased by 54% in paroxetine-treated subjects. Nortriptylin...Continue Reading

Citations

Apr 17, 2001·Depression and Anxiety·D L Dunner
Jul 17, 2007·European Archives of Psychiatry and Clinical Neuroscience·Katherine ShearRussell Sillowash
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Bruce R LawfordTerry L Ritchie
Oct 16, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M Isaac
Jul 28, 2004·BMC Palliative Care·Amanda L ForteChris Feudtner
Sep 7, 2011·Archives of General Psychiatry·Nadine M MelhemDavid A Brent
Sep 27, 2013·Current Psychiatry Reports·M Katherine ShearKim Glickman
Aug 22, 2008·Journal of Gerontological Nursing·Mary E Minton, Cecilia R Barron
Jul 4, 2008·Journal of Affective Disorders·Paula L HensleyPaula J Clayton
Mar 14, 2008·Psychiatry Research·Naomi M SimonRussell Silowash
Apr 11, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Nadine M MelhemDavid Brent
Sep 24, 2004·Clinical Psychology Review·Wendy G LichtenthalHolly G Prigerson
Feb 7, 2006·Journal of Affective Disorders·Paula L Hensley
Jun 19, 2008·NeuroImage·Mary-Frances O'ConnorMatthew D Lieberman
Apr 15, 2010·Nurse Education Today·Ching-Kuei ChiangRuth Elder
Mar 29, 2003·Current Medical Research and Opinion·Ben Green
Dec 17, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·John S Ogrodniczuk, William E Piper
Jul 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Satomi Nakajima
Jun 6, 2017·Journal of Korean Medical Science·Hyesung HanJeong Ho Chae
May 20, 2017·Clinical Journal of Oncology Nursing·Cindy S TofthagenSusan C McMillan
Jan 8, 2021·Frontiers in Psychiatry·Sara PintoRui Coelho
Apr 25, 2021·Nursing Philosophy : an International Journal for Healthcare Professionals·Janni Dahlgaard Gravesen, Regner Birkelund

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

© 2022 Meta ULC. All rights reserved