A post-hoc Unweighted Analysis of Counter-Matched Case-Control Data

The International Journal of Biostatistics
Cyril Rakovski, B Langholz

Abstract

Informative sampling based on counter-matching risk set subjects on exposure correlated with a variable of interest has been shown to be an efficient alternative to simple random sampling; however, the opposite is true when correlation between the two covariates is absent. Thus, the counter-matching design will entail substantial gains in statistical efficiency compared to simple random sampling at a first stage of analyses focused by design on variables correlated with the counter-matching variable but will lose efficiency at a second stage of analyses aimed at variables independent of the counter-matching variable and not conceived as a part of the initial study. In an effort to recover efficiency in such second stage of analyses scenarios, we considered a naive analysis of the effect of a dichotomous covariate on the disease rates in the population that ignores the underlying counter-matching sampling design. We derive analytical expressions for the bias and variance and show that when the counter-matching and the new dichotomous variable of interest are uncorrelated and a multiplicative main effects model holds, such an analysis is advantageous over the standard "weighted" approach, especially when the counter-matching vari...Continue Reading

References

Nov 1, 1994·Environmental Health Perspectives·B Langholz, D Clayton
May 1, 1997·Epidemiology·K Steenland, J A Deddens
Aug 23, 2003·Biostatistics·B Langholz, L Goldstein
Apr 16, 2004·Breast Cancer Research : BCR·Jonine L BernsteinUNKNOWN WECARE study

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