PMID: 3320535Jan 1, 1987Paper

A postulated role for naturally occurring aromatase inhibitors in follicle selection

Journal of Steroid Biochemistry
G S diZeregaG Westhof

Abstract

The studies reviewed here indicate that follicle regulatory protein (FRP) alters aromatase and 3B-hydroxysteroid dehydrogenase activity in porcine, human, and rat granulosa cells. The inhibitory effect of FRP on granulosal aromatase activity depend upon the response of the cell to FSH: large amounts of FSH can partially overcome FRP inhibition while relatively small amounts of FSH sensitize the granulosal aromatase system to FRP. Although androgens potentiate FSH-mediated granulosal functions, they also sensitize granulosa cell steroidogenic enzymes to inhibition by FRP. The demonstration that FRP acts primarily on granulosa cells of less mature antral follicles to inhibit aromatase supports the hypothesis that FRP may facilitate follicle selection and suggests a role for FRP in atresia. Most of the effects of FRP on granulosal activities reflect an interplay between the systemic endocrine and local paracrine systems. That FRP functions, at least in part, by modulating follicular response to FSH is consistent with the hypothesis that paracrine effectors are important mediators of folliculogenesis in the presence of gonadotropins.

References

Sep 1, 1977·Journal of Reproduction and Fertility·H R LindnerY Koch
Nov 1, 1978·Clinics in Endocrinology and Metabolism·K P McNatty
Oct 1, 1978·Biology of Reproduction·A N Hirshfield, A R Midgley
Jun 1, 1978·The Journal of Endocrinology·R M MoorD G Cran
Jun 1, 1990·Gynecologic Oncology·K E RodgersG S diZerega
Feb 1, 1986·Clinics in Endocrinology and Metabolism·S A Tonetta, G S diZerega
May 1, 1989·Endocrine Reviews·S A Tonetta, G S diZerega
Sep 1, 1985·Journal of Reproduction and Fertility·K P McNattyL E Kieboom
Dec 1, 1986·American Journal of Obstetrics and Gynecology·J R Schreiber, G S diZerega
Mar 1, 1987·Biology of Reproduction·I TsutsumiG S diZerega
Jul 1, 1985·Molecular and Cellular Endocrinology·S ChariI Schüler
Aug 1, 1985·Experimental and Clinical Endocrinology·K J ShawG S diZerega
Nov 1, 1985·Journal of Reproduction and Fertility·L P CahillJ K Findlay
Feb 1, 1986·The Journal of Clinical Endocrinology and Metabolism·K ChikazawaT Tamada
Jan 1, 1983·The Journal of Clinical Endocrinology and Metabolism·G S diZeregaO R Kling
Jan 1, 1983·The Journal of Clinical Endocrinology and Metabolism·G S diZeregaO R Kling

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Citations

Dec 1, 1987·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·B D Albertson, M J Zinaman
Jun 14, 2000·Animal Reproduction Science·O J Ginther
May 16, 2001·Biochemical and Biophysical Research Communications·B SaidD C Matsumoto

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