PMID: 2418156Dec 1, 1985

A potential application for the intracerebral injection of drugs entrapped within liposomes in the treatment of human cerebral gliomas

Journal of Neurology, Neurosurgery, and Psychiatry
R O McKeranS O'Laoire

Abstract

After intravenous injection of therapeutic doses of bleomycin only small amounts could be measured in glioma tissue obtained at operation in patients with malignant gliomas and the drug was rapidly cleared from the blood (T1/2 = 2 hrs). Negatively charged liposomes injected through Ommaya reservoirs into the glioma tumour bed were tolerated without observable side effect. The appearance of bleomycin in the blood and urinary clearance after intracerebral injection of bleomycin entrapped within negatively charged liposomes through an Ommaya reservoir in patients with malignant gliomas was decreased as compared with levels when free bleomycin was injected. These preliminary observations suggest a role of drugs entrapped within liposomes as a depot preparation in the treatment of human cerebral gliomas.

References

Apr 1, 1976·Journal of Neurology, Neurosurgery, and Psychiatry·T HayakawaH Mogami
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·F Szoka, D Papahadjopoulos
Apr 1, 1979·The Journal of Endocrinology·W A LuqmanM L Smith
Mar 1, 1977·Journal of the Neurological Sciences·D H AdamsH M Wiśniewski
Jan 1, 1976·Southern Medical Journal·P R Bergevin, J Blom
Apr 1, 1985·Journal of the Neurological Sciences·A S OliverR O McKeran
Mar 1, 1974·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T HayakawaK Horibata
Jun 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·G B FirthR O McKeran
Jan 1, 1980·Acta neurochirurgica·D SchifferL Tarenzi

Citations

Feb 1, 1991·Journal of Neuro-oncology·T Tomita
Oct 27, 2009·Cancer Chemotherapy and Pharmacology·Sharon ConroyDavid Walker
Apr 1, 1985·Journal of the Neurological Sciences·A S OliverR O McKeran
Dec 1, 1995·Neurosurgery·K A WalterH Brem
Jun 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P TurskiS Kornguth

Related Concepts

Brain Tumor, Recurrent
Dose-Response Relationship, Drug
Glioblastoma Multiforme
Mixed Gliomas
Intravenous Injections
Niosomes
Total Body Clearance Rate

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