A potential biomarker hsa-miR-200a-5p distinguishing between benign thyroid tumors with papillary hyperplasia and papillary thyroid carcinoma

PloS One
Xian WangZhengsheng Wu

Abstract

Papillary thyroid carcinoma (PTC) is the most common endocrine cancer with a significantly increase of the incidence recently. Several cytokines, such as thyroid peroxidase (TPO), cluster of differentiation 56 (CD56), Galectin-3, mesothelial cell (MC), cytokeratin 19 (CK19) and BRAF (B-raf) were recommended to be tested by immunohistochemistry (IHC) for a definitive diagnosis, but were still limited in clinical use because of their relative lower sensitivity and specificity. MicroRNA (miRNA), as a new molecular biomarkers, however, has not been reported yet so far. To address this, hsa-miR-200a-5p, a miRNA, was selected and detected in PTC patients by in situ hybrization with benign thyroid tumor with papillary hyperplasia as a control, and the differential expression of hsa-miR-200a-5p between fresh PTC tissues and control was detected by qRT-PCR. Expressive levels of cytokines of TPO, CD56, Galectin-3, MC, CK19 and B-raf were also detected by immunohistochemistry. The correlation was analyzed by SPSS software using Spearman methods. As expected, the hsa-miR-200a-5p expressive level was significantly increased in PTC patients, compared to that of control, and was consistent with that of TPO, CD56, Galectin-3, MC, CK19 and B-ra...Continue Reading

References

May 14, 2005·Virchows Archiv : an International Journal of Pathology·Bogdan GaluscaMichel Peoc'h
Jul 17, 2012·International Journal of Molecular Medicine·Zhe ZhangYou-Yuan Zhang
Jan 1, 2013·Molecular Biology Reports·Xinyan HouXiangtao Kang
Feb 9, 2013·Journal of Endocrinological Investigation·C M Pacella, E Papini
Nov 25, 2014·Cell·UNKNOWN Cancer Genome Atlas Research Network
Dec 4, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hwei-Fang TsaiPing-Ning Hsu
May 25, 2016·Thyroid : Official Journal of the American Thyroid Association·Kristine S WongJustine A Barletta
Jul 15, 2016·Thyroid : Official Journal of the American Thyroid Association·Doh Young LeeYoung Joo Park
Sep 14, 2016·The Journal of Clinical Endocrinology and Metabolism·Shinya UchinoToshiyuki Sakai
Oct 16, 2016·Virchows Archiv : an International Journal of Pathology·Oleksandr N KryvenkoMerce Jorda
Nov 13, 2016·Biomolecular Concepts·Daniel SenfterRobert M Mader
Dec 14, 2016·Molecular Medicine Reports·Mingwen HaoWenjun Li
Jan 24, 2017·JAMA Oncology·Maria Nirvana da Cruz FormigaMaria Isabel Achatz
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Nicholas E KhanDouglas R Stewart
Apr 15, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L Dal MasoUNKNOWN EUROCARE-5 Working Group
May 31, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B Xu, R Ghossein
Jun 15, 2017·The Journal of Clinical Endocrinology and Metabolism·Danae A DelivanisMabel Ryder
Jun 29, 2017·Archives of Endocrinology and Metabolism·Léa Maria Zanini Maciel, Patrícia Künzle Ribeiro Magalhães
Jul 12, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Benjamin R RomanLouise Davies
Oct 11, 2017·Journal of Pathology and Translational Medicine·Hyo Jung AnDae Hyun Song
Oct 17, 2017·Thyroid : Official Journal of the American Thyroid Association·Kathrin A SchmohlChristine Spitzweg
Oct 21, 2017·Oncotarget·Madhusudhan Reddy BobbiliHanna Dellago
Nov 1, 2017·Methods in Molecular Biology·Wani ArjumandShiekh Tanveer Ahmad
Nov 1, 2017·Methods in Molecular Biology·Wei CaoWei Wu
Nov 1, 2017·Methods in Molecular Biology·Jun ZhuWei Wu
Nov 1, 2017·Methods in Molecular Biology·Wei Wu

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Oct 11, 2019·Current Opinion in Oncology·Stefania BulottaDiego Russo

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