PMID: 9533141Apr 9, 1998Paper

A potential diagnostic application of magnetization transfer contrast: an in vitro NMR study of excised human thyroid tissues

Physics in Medicine and Biology
C Callicott, A W Goode

Abstract

A series of freshly excised thyroid tissues was analysed using a nuclear magnetic resonance spectrometer and then subjected to routine histo-pathology examination. Whilst simple T1 values for normal tissue and goitre are not significantly different, the degree of intra-subject T1 and T1s variability is shown to be an indicator of benign thyroid disease. Using data collected from an inversion-recovery sequence performed with and without magnetization transfer, a magnetization transfer rate constant was calculated for each tissue sample. These data suggest that this parameter may provide in vivo discrimination between follicular cancer and follicular adenoma.

References

Apr 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S D Wolff, R S Balaban
Sep 1, 1989·Investigative Radiology·M JohnsonL Kwock
Oct 1, 1988·The British Journal of Surgery·E L CusickN A Matheson
Apr 1, 1987·The British Journal of Surgery·J B Anderson, A J Webb
Apr 6, 1985·British Medical Journal·A D Toft
Mar 1, 1996·Journal of Magnetic Resonance. Series B·A RutterC E Mountford

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Citations

Sep 24, 1999·Physics in Medicine and Biology·C Callicott
Jun 15, 1999·Physics in Medicine and Biology·C CallicottA W Goode

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