A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder

Scientific Reports
Liang-Jen WangRu-Band Lu

Abstract

Bipolar II disorder (BP-II), characterized by recurrent dysregulation of mood, is a serious and chronic psychiatric illness. However, BP-II is commonly under-recognized, even in psychiatric settings. Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransferase (COMT) gene, which are involved in dopamine metabolism, and the methylenetetrahydrofolate reductase (MTHFR) gene, which may affect COMT methylation and COMT function. The current study examined the association and interaction of the COMT Val158Met and MTHFR C677T variants with BP-II. Nine hundred seventy-eight participants were recruited: 531 with BP-II and 447 healthy controls. The genotypes of the COMT and MTHFR polymorphisms were determined using a polymerase chain reaction-restriction fragment length polymorphism analysis. Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype (P = 0.039) for the protective effect on the odds of developing BP-II. Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and t...Continue Reading

References

Jul 1, 1978·Archives of General Psychiatry·J Endicott, R L Spitzer
Nov 1, 1983·Psychological Medicine·E H Reynolds, G Stramentinoli
Mar 1, 1995·The American Journal of Psychiatry·W CoryellH S Akiskal
Oct 17, 1998·Molecular Psychiatry·H KunugiS Nanko
Dec 19, 1998·Journal of Affective Disorders·J Angst
Nov 7, 1999·The Psychiatric Clinics of North America·H S Akiskal, O Pinto
Nov 7, 1999·The Psychiatric Clinics of North America·Z Rihmer, P Pestality
Nov 15, 2000·The Journal of Clinical Psychiatry·S N GhaemiF K Goodwin
Mar 10, 2001·Psychiatric Services : a Journal of the American Psychiatric Association·G M MacQueen, L T Young
Feb 15, 2002·Bipolar Disorders·N CraddockJ Greening
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simonetta FrisoJacob Selhub
Jan 1, 2003·Journal of Affective Disorders·Franco Benazzi, Hagop S Akiskal
Aug 5, 2003·Bipolar Disorders·Kenji J TsuchiyaPreben B Mortensen
May 28, 2004·Nature·Christopher S CarlsonDeborah A Nickerson
Mar 3, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Jules Angst
Jan 11, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Joshua L RoffmanDonald C Goff
Nov 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joshua L RoffmanDara S Manoach
Jun 1, 2006·Nutrition Research Reviews·C Sugden
Jan 31, 2009·Nutritional Neuroscience·Constanza del Río GarciaLizbeth López-Carrillo
Nov 10, 2009·Behavior Research Methods·Franz FaulAlbert-Georg Lang
Apr 24, 2010·CNS Spectrums·Stephen M Stahl
Jun 17, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sarah Cohen-WoodsAnne Farmer
May 3, 2011·Biological Psychiatry·Roshan Cools, Mark D'Esposito
May 21, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Inés AncínAna Barabash
Aug 6, 2011·European Archives of Psychiatry and Clinical Neuroscience·J AngstA H Young
Oct 3, 2012·Behavioural Brain Research·Sheng-Yu LeeRu-Band Lu
Jan 29, 2013·Neuroscience Letters·Dimitrios KontisEleftheria Tsaltas
Nov 28, 2013·Psychiatric Genetics·Mohamed A El-HadidyMohammad Al-Harrass

❮ Previous
Next ❯

Citations

Sep 28, 2017·The International Journal of Neuroscience·Victor MarinhoSilmar Teixeira
Aug 9, 2018·Journal of Biomedical Science·Victor MarinhoSilmar Teixeira
Aug 7, 2020·Neuroscience and Biobehavioral Reviews·Hugo Sérgio AlmeidaAntonio Benabarre
Dec 18, 2020·Frontiers in Genetics·Janice ForsterMerlin G Butler

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

SPSS
Power

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Sheng-Yu LeeRu-Band Lu
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Chih-Chun HuangRu-Band Lu
The International Journal of Neuropsychopharmacology
Tzu-Yun WangRu-Band Lu
© 2022 Meta ULC. All rights reserved