A potential mechanism of energy-metabolism oscillation in an aerobic chemostat culture of the yeast Saccharomyces cerevisiae

The FEBS Journal
Zhaojun Xu, Kunio Tsurugi

Abstract

The energy-metabolism oscillation in aerobic chemostat cultures of yeast is a periodic change of the respiro-fermentative and respiratory phase. In the respiro-fermentative phase, the NADH level was kept high and respiration was suppressed, and glucose was anabolized into trehalose and glycogen at a rate comparable to that of catabolism. On the transition to the respiratory phase, cAMP levels increased triggering the breakdown of storage carbohydrates and the increased influx of glucose into the glycolytic pathway activated production of glycerol and ethanol consuming NADH. The resulting increase in the NAD(+)/NADH ratio stimulated respiration in combination with a decrease in the level of ATP, which was consumed mainly in the formation of biomass accompanying budding, and the accumulated ethanol and glycerol were gradually degraded by respiration via NAD(+)-dependent oxidation to acetate and the respiratory phase ceased after the recovery of NADH and ATP levels. However, the mRNA levels of both synthetic and degradative enzymes of storage carbohydrates were increased around the early respiro-fermentative phase, when storage carbohydrates are being synthesized, suggesting that the synthetic enzymes were expressed directly as ac...Continue Reading

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Citations

Feb 3, 2009·Applied Biochemistry and Biotechnology·Chris C StowersErik M Boczko
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·J Brian RobertsonCarl Hirschie Johnson
Nov 11, 2006·Annual Review of Genetics·Herman Wijnen, Michael W Young
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Jul 20, 2021·IScience·Ana M Matia-GonzálezAndré P Gerber
May 29, 2007·Archives of Biochemistry and Biophysics·Zhaojun Xu, Kunio Tsurugi

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