A potential role for avocado- and soybean-based nutritional supplements in the management of osteoarthritis: a review

The Physician and Sportsmedicine
Nicholas A Dinubile

Abstract

Osteoarthritis (OA) is a common, painful, and debilitating condition that affects approximately 46.4 million individuals in the United States. By 2012, this number is expected to increase to 60 million. In addition, it is the leading cause of activity limitation in adults and represents a widely acknowledged economic burden. Although the ultimate goal is to slow or prevent OA progression, at present, medical management of OA is aimed primarily at controlling symptoms of pain and stiffness and maintaining joint mobility and quality of life. Because of the lack or perceived lack of response to many conventional therapies for OA as well as concerns regarding the long-term administration of drugs (eg, nonsteroidal anti-inflammatory drugs), oral joint health supplements (OJHSs) have become increasingly popular among patients with OA. This article briefly reviews pertinent molecular mechanisms involved in the development of OA and summarizes available in vitro and in vivo evidence supporting the use of avocado and soybean unsaponifiables (ASU) either alone or in combination with glucosamine and chondroitin sulfate in patients with OA. Basic scientific research studies and a systematic review and meta-analysis of the available high-qu...Continue Reading

References

Jun 1, 1980·Planta medica·M B GuptaK P Bhargava
Dec 1, 1994·The Journal of Clinical Investigation·M B GoldringJ F Apperley
Jun 2, 1998·The Annals of Pharmacotherapy·T S BarclayG M McCart
Sep 23, 1998·Osteoarthritis and Cartilage·F RoncaG Ronca
Oct 20, 1999·Frontiers in Bioscience : a Journal and Virtual Library·G A Homandberg
Jun 28, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·P M van der Kraan, W B van den Berg
Jul 25, 2000·Osteoarthritis and Cartilage·J I FentonM W Orth
Dec 29, 2000·Clinical Orthopaedics and Related Research·L LippielloT A Hammad
Nov 14, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·P J Bouic
Apr 5, 2002·Arthritis and Rheumatism·Michel LequesneRenèe-Liliane Dreiser
Aug 14, 2003·The Journal of Nutritional Biochemistry·Ariënne de JongRonald P Mensink
Feb 1, 1965·Arthritis and Rheumatism·M WALLERL THURMAN
Aug 18, 2004·Current Opinion in Rheumatology·Francis Berenbaum
Dec 29, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J W AndersonJ F Borzelleca
Jan 26, 2005·Archives of Internal Medicine·Marisa BattistellaAndreas Laupacis
Mar 8, 2005·Arthritis and Rheumatism·Beat A MichelDaniel Uebelhart
Feb 24, 2006·The New England Journal of Medicine·Daniel O CleggH James Williams
Oct 10, 2006·Vitamins and Hormones·Claire JacquesCem Gabay
Apr 18, 2007·Current Rheumatology Reports·Tracy M Frech, Daniel O Clegg
May 3, 2007·The Journal of Bone and Joint Surgery. American Volume·James G Wright
Jun 6, 2007·Evidence-based Complementary and Alternative Medicine : ECAM·Louis Lippiello
Jul 4, 2007·American Journal of Veterinary Research·Pooi-See ChanMichael W Orth
Jan 1, 2008·Arthritis and Rheumatism·Charles G HelmickUNKNOWN National Arthritis Data Workgroup
Jan 1, 2008·Arthritis and Rheumatism·Reva C LawrenceUNKNOWN National Arthritis Data Workgroup
Jun 7, 2008·The Journal of Arthroplasty·Steven M KurtzEdmund Lau
Jul 8, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Louis LippielloTiffany Chiou
Dec 20, 2008·The Journal of International Medical Research·E C Huskisson
Jun 2, 2009·Journal of the American Veterinary Medical Association·Stacey L Oke
Jul 31, 2009·Postgraduate Medicine·Nicholas A DiNubile
Aug 12, 2009·Journal of Pain & Palliative Care Pharmacotherapy·UNKNOWN U.S. Food and Drug Administration

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Citations

May 4, 2013·Critical Reviews in Food Science and Nutrition·Mark L Dreher, Adrienne J Davenport
Dec 19, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Aida LazkaniLaurent Becquemont
May 20, 2016·Glycoconjugate Journal·Mamta BishnoiSanjay K Jain
Jan 27, 2015·Cartilage·Blaine A ChristiansenShahin Emami
Apr 20, 2020·Journal of Biophotonics·Xiaobo LinKatarina Svanberg

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