A potential role for Drosophila mucins in development and physiology.

PloS One
Zulfeqhar A SyedIris F van Dijk-Härd

Abstract

Vital vertebrate organs are protected from the external environment by a barrier that to a large extent consists of mucins. These proteins are characterized by poorly conserved repeated sequences that are rich in prolines and potentially glycosylated threonines and serines (PTS). We have now used the characteristics of the PTS repeat domain to identify Drosophila mucins in a simple bioinformatics approach. Searching the predicted protein database for proteins with at least 4 repeats and a high ST content, more than 30 mucin-like proteins were identified, ranging from 300-23000 amino acids in length. We find that Drosophila mucins are present at all stages of the fly life cycle, and that their transcripts localize to selective organs analogous to sites of vertebrate mucin expression. The results could allow for addressing basic questions about human mucin-related diseases in this model system. Additionally, many of the mucins are expressed in selective tissues during embryogenesis, thus revealing new potential functions for mucins as apical matrix components during organ morphogenesis.

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Citations

May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Liping ZhangKelly G Ten Hagen
Nov 26, 2014·Nature Reviews. Immunology·Nicolas BuchonSara Cherry
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Takayuki KuraishiBruno Lemaitre
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Jan 12, 2016·PLoS Genetics·Sibylle Chantal VoneschErnst Hafen
Jan 31, 2019·BMC Evolutionary Biology·Jean-Luc Da LageVirginie Courtier-Orgogozo
Feb 11, 2020·Frontiers in Cellular and Infection Microbiology·Poliana Fernanda GiachettoRenato Andreotti
Nov 7, 2019·The Journal of Biological Chemistry·Hayley M ReynoldsKelly G Ten Hagen
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May 20, 2020·Insect Biochemistry and Molecular Biology·Xiaoming ZhaoQing Yang
Nov 18, 2021·Genome Biology and Evolution·Flora BorneVirginie Courtier-Orgogozo

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Methods Mentioned

BETA
PCR
affinity-purification
glycosylation
Reverse Transcription PCR

Software Mentioned

PTSP
BLAST
- Miner
Miner
PTS P attern - Miner
BioJava

Related Concepts

Related Feeds

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