A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea

Cell Reports Medicine
Sunaina RengarajanChyi-Song Hsieh

Abstract

Stress is a known trigger for flares of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS); however, this process is not well understood. Here, we find that restraint stress in mice leads to signs of diarrhea, fecal dysbiosis, and a barrier defect via the opening of goblet-cell associated passages. Notably, stress increases host immunity to gut bacteria as assessed by immunoglobulin A (IgA)-bound gut bacteria. Stress-induced microbial changes are necessary and sufficient to elicit these effects. Moreover, similar to mice, many diarrhea-predominant IBS (IBS-D) patients from two cohorts display increased antibacterial immunity as assessed by IgA-bound fecal bacteria. This antibacterial IgA response in IBS-D correlates with somatic symptom severity and was distinct from healthy controls or IBD patients. These findings suggest that stress may play an important role in patients with IgA-associated IBS-D by disrupting the intestinal microbial community that alters gastrointestinal function and host immunity to commensal bacteria.

References

Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Dec 21, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J D Söderholm, M H Perdue
Mar 27, 2002·Psychosomatic Medicine·Kurt KroenkeJanet B W Williams
Jan 4, 2003·Nature Reviews. Immunology·Sidonia Fagarasan, Tasuku Honjo
Apr 19, 2005·Journal of Neuroimmunology·Andrea EnglerJohn F Sheridan
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Jul 31, 2007·Alimentary Pharmacology & Therapeutics·M ThabaneJ K Marshall
Dec 17, 2008·Mucosal Immunology·A J MacphersonP Brandtzaeg
May 29, 2009·BMC Bioinformatics·Weijun LuoPeter J Woolf
Feb 16, 2010·The Journal of Allergy and Clinical Immunology·Angela Haczku, Reynold A Panettieri
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·J Gregory CaporasoRob Knight
Jan 8, 2011·Nature Reviews. Gastroenterology & Hepatology·Jane M Andrews, Gerald Holtmann
Mar 19, 2011·BMC Bioinformatics·Xavier RobinMarkus Müller
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Sep 23, 2011·Nature·Stephanie K LathropChyi-Song Hsieh
Oct 25, 2011·Cell Host & Microbe·Diane Mathis, Christophe Benoist
Aug 30, 2012·The American Journal of Gastroenterology·Stephen J Halpin, Alexander C Ford
Oct 30, 2012·Nature Reviews. Immunology·Oliver Pabst
Oct 30, 2012·Bioinformatics·Alexander DobinThomas R Gingeras
Feb 7, 2013·Trends in Neurosciences·Jane A Foster, Karen-Anne McVey Neufeld
Feb 15, 2013·Immunological Reviews·Matthew ShaleFiona Powrie
Oct 24, 2014·World Journal of Gastroenterology : WJG·Hong-Yan QinZhao-Xiang Bian
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders

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Citations

Jun 3, 2021·International Journal of Molecular Sciences·Fabiola Guzmán-MejíaMaria Elisa Drago-Serrano
Jul 2, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chyi-Song HsiehNadia N Hansel
Aug 17, 2021·Frontiers in Microbiology·Nicole RodriguezAnita L Kozyrskyj

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Datasets Mentioned

BETA
PRJEB40130

Methods Mentioned

BETA
biopsies
transgenic
flow cytometry
RNA-seq
fluorescence-activated cell sorting
chip
ELISA
flow cytometery
PCR
FACS

Software Mentioned

R
IDT
featureCount
Ensembl
Bioconductor package EdgeR
UPARSE
dada2
stats
gbm R package
Pathview

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