A potential role for the midbrain in integrating fat-free mass determined energy needs: An H2 (15) O PET study

Human Brain Mapping
C M WeiseJ Krakoff

Abstract

Little is known on how sensing of energy needs is centrally represented, integrated, and translated into the behavioral aspects of energy homeostasis. Fat free mass (FFM) is the major determinant of energy expenditure. We investigated how interindividual variances in FFM relate to neuronal activity in humans. Healthy adults (n = 64, 21F/43M; age 31.3 ± 9.1y; percentage of body fat [PFAT] 25.6 ± 10.7%; BMI 30.4 ± 9) underwent a 36h fast and subsequent H(2) (15) O positron emission tomographic (PET) measurement of regional cerebral blood flow (rCBF). Multiple variable regression analysis revealed significant associations of FFM with rCBF within the midbrain [including parts of the periaqueductal gray (PAG), ventral tegmental area (VTA), thalamic and hypothalamic regions], the bilateral parahippocampal region, left anterior cingulate, left insular cortex, right cerebellum, and distinct regions within the temporal and occipital cortex. In contrast, no significant associations were found for fat mass (FM). We investigated the potential functional-anatomical link between FFM and central regulation of food intake by performing a conjunction analysis of FFM and the perceived hunger feelings. This showed a significant overlap within the...Continue Reading

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Citations

Dec 6, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C M WeiseB Pleger
Dec 15, 2016·European Journal of Clinical Nutrition·A G DullooY Schutz
Apr 11, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patricia ClementEric Achten
Jan 25, 2018·International Journal of Environmental Research and Public Health·Masahiro Okada
Mar 22, 2018·European Journal of Clinical Nutrition·Abdul G DullooYves Schutz
Jun 23, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alex ReichenbachZane B Andrews
Aug 1, 2018·Expert Review of Endocrinology & Metabolism·Mark HopkinsJohn E Blundell
May 3, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Mark HopkinsR James Stubbs

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