A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease

Journal of Enzyme Inhibition and Medicinal Chemistry
R TundisF Menichini

Abstract

From the aerial parts of Salsola oppositofolia, S. soda and S. tragus an alkaloid extract was obtained and tested to evaluate antioxidant and anti-cholinesterase activities. The in vitro study of the antioxidant activity by the DPPH method revealed a significant activity of Salsola alkaloid extracts with IC(50) values ranging from 16.30 microg/mL for S. oppositifolia to 26.17 microg/mL for S. tragus. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities were evaluated. S. tragus alkaloid extract exerted the highest inhibitory activity against AChE (IC(50) of 30.2 microg/mL) and BChE (IC(50) of 26.5 microg/mL). Interestingly, S. soda and S. oppositifolia exhibited a selective inhibitory activity against BChE with IC(50) values of 34.3 microg/mL and 32.7 microg/mL, respectively. Tetrahydroisoquinoline alkaloids were identified and quantified by GC/MS analysis.

References

Jul 1, 1978·Neuropathology and Applied Neurobiology·E K PerryB E Tomlinson
Jan 1, 1986·British Journal of Clinical Pharmacology·A M Breckenridge
Jul 1, 1984·Canadian Journal of Physiology and Pharmacology·P L McGeer
Nov 7, 2000·The American Journal of Medicine·D Praticò, N Delanty
Feb 22, 2001·Free Radical Biology & Medicine·R RadiA Cayota
Mar 15, 2003·International Psychogeriatrics·Nigel H GreigKumar Sambamurti
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Dec 15, 2004·Archives of Pharmacal Research·Dae Keun KimJae Soon Eun
Apr 28, 2005·Expert Review of Neurotherapeutics·Andrea TaskerClive G Ballard
Jun 25, 2005·Current Alzheimer Research·Clive G BallardSultan Darvesh
Feb 18, 2006·Bioorganic & Medicinal Chemistry Letters·Sutthatip MarkmeeNantaka Khorana
Dec 29, 2006·Journal of Molecular Neuroscience : MN·M E Hasselmo, L M Giocomo
Feb 24, 2007·Bioorganic & Medicinal Chemistry Letters·Sylvain AubryMarc Lemaire
Mar 10, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Pulok K MukherjeePeter J Houghton

❮ Previous
Next ❯

Citations

Sep 14, 2013·Natural Product Research·Dalia M RasheedMohamed A Farag
May 1, 2010·Journal of Enzyme Inhibition and Medicinal Chemistry·Marco BonesiFrancesco Menichini
Mar 29, 2014·Redox Report : Communications in Free Radical Research·Heba A AnissCamelia Adly
Apr 22, 2015·Journal of Environmental Management·Tiziana Centofanti, Gary Bañuelos
Nov 13, 2010·Natural Product Reports·Philip WilliamsMelanie-Jayne R Howes
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hamdoon A MohammedRiaz A Khan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.