A Potential Role of Interleukin 10 in COVID-19 Pathogenesis

Trends in Immunology
Ligong LuYou-Wen He

Abstract

A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL-10 elevation may play a pathological role in COVID-19 severity.

Citations

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NCT04320615
NCT02009449
NCT03267732

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