A power comparison of generalized additive models and the spatial scan statistic in a case-control setting.

International Journal of Health Geographics
Robin L YoungThomas Webster

Abstract

A common, important problem in spatial epidemiology is measuring and identifying variation in disease risk across a study region. In application of statistical methods, the problem has two parts. First, spatial variation in risk must be detected across the study region and, second, areas of increased or decreased risk must be correctly identified. The location of such areas may give clues to environmental sources of exposure and disease etiology. One statistical method applicable in spatial epidemiologic settings is a generalized additive model (GAM) which can be applied with a bivariate LOESS smoother to account for geographic location as a possible predictor of disease status. A natural hypothesis when applying this method is whether residential location of subjects is associated with the outcome, i.e. is the smoothing term necessary? Permutation tests are a reasonable hypothesis testing method and provide adequate power under a simple alternative hypothesis. These tests have yet to be compared to other spatial statistics. This research uses simulated point data generated under three alternative hypotheses to evaluate the properties of the permutation methods and compare them to the popular spatial scan statistic in a case-co...Continue Reading

References

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Oct 16, 2010·Computational Statistics & Data Analysis·Robin L YoungThomas F Webster
Jun 28, 2011·Journal of Biometrics & Biostatistics·Robin Y BlissThomas F Webster

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Citations

Jun 12, 2012·Spatial and Spatio-temporal Epidemiology·David C WheelerMary H Ward
Jul 4, 2012·Spatial and Spatio-temporal Epidemiology·Robin L BlissThomas F Webster
Dec 4, 2015·PLoS Neglected Tropical Diseases·Adam AkullianJoel M Montgomery
Feb 1, 2018·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Verónica M VieiraMarc G Weisskopf
Jul 17, 2019·BMC Medical Research Methodology·Abdoulaye GuindoJean Gaudart
Jul 25, 2020·Statistics in Medicine·Anny-Claude JosephDavid C Wheeler
Jun 5, 2021·Environmental Research·John L PearceUNKNOWN program collaborators for Environmental influences on Child Health Outcomes

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Methods Mentioned

BETA
GAM

Software Mentioned

R
SaTScan
gam

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