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A powerful and efficient set test for genetic markers that handles confounders

Bioinformatics

Apr 20, 2013

Jennifer ListgartenDavid Heckerman

Abstract

Approaches for testing sets of variants, such as a set of rare or common variants within a gene or pathway, for association with complex traits are important. In particular, set tests allow for aggregation of weak signal within a set, can capture interplay among variants and reduce the ...read more

Mentioned in this Paper

Genome-Wide Association Study
Biochemical Pathway
IIeocolitis
Log-Linear Models
Genetic Analysis
Genetic Screening Method
Aggregation
Genetic Markers
Genes, vif
Nested Case-Control Studies
7
1
144
Paper Details
References
  • References40
  • Citations30
1234
  • References40
  • Citations30
123

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A powerful and efficient set test for genetic markers that handles confounders

Bioinformatics

Apr 20, 2013

Jennifer ListgartenDavid Heckerman

PMID: 23599503

DOI: 10.1093/bioinformatics/btt177

Abstract

Approaches for testing sets of variants, such as a set of rare or common variants within a gene or pathway, for association with complex traits are important. In particular, set tests allow for aggregation of weak signal within a set, can capture interplay among variants and reduce the ...read more

Mentioned in this Paper

Genome-Wide Association Study
Biochemical Pathway
IIeocolitis
Log-Linear Models
Genetic Analysis
Genetic Screening Method
Aggregation
Genetic Markers
Genes, vif
Nested Case-Control Studies
7
1
144

Feeds With Similar Papers

Inflammatory Bowel Disease

Inflammatory bowel diseases (IBD), Crohn’s disease and ulcerative colitis, arise due to chronic inflammation of the gastrointestinal tract. Here is the latest research.

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Paper Details
References
  • References40
  • Citations30
1234
  • References40
  • Citations30
123

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