A Practical and Chemoselective Ammonia-Free Birch Reduction

Organic Letters
Peng LeiJie An

Abstract

A novel protocol for a significantly improved, practical, and chemoselective ammonia-free Birch reduction mediated by bench-stable sodium dispersions and recoverable 15-crown-5 ether is reported. A broad range of aromatic and heteroaromatic compounds is reduced with excellent yields.

References

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Citations

Aug 6, 2019·Angewandte Chemie·Anamitra Chatterjee, Burkhard König
Nov 9, 2019·Organic & Biomolecular Chemistry·Robert R A FreundHans-Dieter Arndt
May 21, 2020·Nature Communications·Rory C McAteeCorey R J Stephenson

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