A practical concept for preoperative identification of patients with impaired primary hemostasis

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Juergen KoscielnyReinhard Latza

Abstract

The findings of a large prospective study designed to identify primary and/or secondary hemostatic disorders before surgical interventions are presented. A total of 5649 unselected adult patients were enrolled to identify impaired hemostasis before surgical interventions. Each patient was asked to answer a standardized questionnaire concerning bleeding history. Activated partial thromboplastin time (aPTT), prothrombin time (PT), and platelet counts (PC) including PFA-100 (platelet function analyzer): collagen-epinephrine (C/E), and collagen-ADP (C/ADP) were routinely done in all patients. Additional tests, bleeding time (BT), and von Willebrand factor (vWF: Ag) were performed only in patients with a positive bleeding history and/or evidence of impaired hemostasis; e.g., drug ingestion. The bleeding history was negative in 5021 patients (88.8%) but positive in the remaining 628 (11.2%). Impaired hemostasis could be verified only in 256 (40.8%) of these patients. The vast majority were identified with PFA-100: C/E (n=250; 97.7%). The other six patients with impaired hemostasis were identifiable solely based on the PT (n=2), PFA-100: C/ADP (n=2), and vWF: Ag (n=2). The PFA-100: C/ADP detected 199 patients (77.7%). The only abnorma...Continue Reading

References

Oct 1, 1978·Scandinavian Journal of Haematology·C EikaH C Godal
Jan 3, 1991·The New England Journal of Medicine·J N George, S J Shattil
Jan 1, 1990·Seminars in Thrombosis and Hemostasis·R P Rodgers, J Levin
Nov 1, 1988·Annals of Surgery·M J RohrerD L Nahrwold
May 1, 1985·The American Journal of Medicine·A BarberC H Ts'ao
Jun 28, 1985·JAMA : the Journal of the American Medical Association·E B KaplanC D Nicoll
Nov 1, 1984·Annals of Surgery·A P Borzotta, M M Keeling
Jul 10, 1995·Archives of Internal Medicine·A SrámekF R Rosendaal
May 14, 1998·Seminars in Thrombosis and Hemostasis·E F MammenD J Nugent
Mar 10, 1999·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·P HarrisonS J Machin
Apr 20, 2004·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Juergen KoscielnyReinhard Latza

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Citations

Nov 1, 2011·Medizinische Klinik, Intensivmedizin und Notfallmedizin·S Petros
Nov 10, 2011·Medizinische Klinik, Intensivmedizin und Notfallmedizin·T Lang
Feb 4, 2005·Der Anaesthesist·C-E Dempfle
Mar 5, 2005·Der Anaesthesist·S A Kozek-LangeneckerUNKNOWN Task Force on Perioperative Coagulation of the Austrian Society for Anesthesiology and Intensive Care Medicine
Dec 1, 2005·Der Anaesthesist·F Gerheuser, D Crass
Apr 14, 2007·Der Anaesthesist·F Gerheuser, A Roth
Mar 4, 2008·Der Anaesthesist·B A Stuck, H V Genzwürker
Sep 4, 2009·Der Anaesthesist·C F WeberK Görlinger
Jul 7, 2011·The Journal of Laryngology and Otology·G Kontorinis, B Schwab
Dec 15, 2010·British Journal of Anaesthesia·J J van VeenM Makris
Oct 19, 2012·British Journal of Anaesthesia·C SolomonP W Collins
Dec 15, 2010·Hämostaseologie·A R Rechner
Mar 19, 2014·Cell Biochemistry and Biophysics·Yang ZhangXiaona Zhang
Apr 10, 2014·Der Internist·R Klamroth
Aug 29, 2012·ISRN Hematology·Ralf KargerVolker Kretschmer
Nov 28, 2013·Musculoskeletal Surgery·A JakoiK Radcliff
Apr 7, 2009·Néphrologie & thérapeutique·Carmen LefaucheurJean Bariety
May 30, 2014·British Journal of Anaesthesia·D AdelmannE Schaden
Jun 27, 2009·Acta neurochirurgica·Ruediger GerlachKlaus Goerlinger
Jun 14, 2012·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·J BeckmannT Becker
Oct 27, 2009·Platelets·Daniel BolligerMiodrag Filipovic
Feb 24, 2009·Platelets·G ScharbertS Kozek-Langenecker
Apr 29, 2015·Expert Review of Hematology·Giuseppe LippiEmmanuel J Favaloro
Oct 9, 2014·International Journal of Molecular Sciences·Reinaldo Barros GeraldoHelena Carla Castro
Oct 26, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Thorsten HaasMarkus Weiss
Nov 5, 2013·The Medical Clinics of North America·Andrea Orfanakis, Thomas Deloughery
Apr 21, 2010·Best Practice & Research. Clinical Anaesthesiology·Petra Innerhofer, Joachim Kienast
Jun 6, 2008·The British Journal of Oral & Maxillofacial Surgery·M ModigA Heimdahl
Apr 4, 2006·The Surgical Clinics of North America·Randall S BurdJoseph D Tobias
Feb 21, 2006·British Journal of Haematology·I Elalamy, M Hatmi
Jan 20, 2006·Journal of Thrombosis and Haemostasis : JTH·C P M HaywardUNKNOWN Platelet Physiology Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis
May 19, 2006·Journal of Thrombosis and Haemostasis : JTH·J KoscielnyG-F von Tempelhoff
Jun 10, 2010·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Andrew P J OlsonGurpreet Dhaliwal
Mar 31, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Birte SporbeckAlexander Nast
Nov 13, 2013·Seminars in Hematology·Serena Valsami, Lars M Asmis
Jun 19, 2016·Transfusion Medicine Reviews·Patrick MeybohmKai Zacharowski
Jun 14, 2016·The Journal of Laryngology and Otology·A PatelA Rachmanidou

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