A Practical Estimation Method for Analyzing Adverse Drug Reactions Using Data Mining

Therapeutic Innovation & Regulatory Science
Yuko ShirakuniTatsuya Takagi

Abstract

This study aimed to determine the potentially severe chemical properties of drugs that can cause adverse drug reactions (ADRs) such as erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) by using a data mining method. The study data were extracted from the Adverse Event Reporting System database of the FDA. EM was considered a mild reaction, and SJS and TEN were considered severe reactions. In this study, a new concept termed the "risk of aggravation" (ROA) was defined as whether a certain drug is more likely to cause severe adverse reactions than mild ones. Partial least squares and logistic regression analysis were applied using binary response variable ROAs. These analyses correctly predicted 50 of the 72 drugs associated with SJS and/or TEN and 28 of the 38 drugs associated with EM using binary chemical descriptors that are the same as those using the metric chemical descriptors.

References

Dec 14, 1995·The New England Journal of Medicine·J C RoujeauF Locati
Jun 28, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·J D McKinneyF Gerberick
Nov 28, 2006·Journal of Chemical Information and Modeling·Hanna Eckert, Jürgen Bajorath

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Citations

Oct 27, 2015·Journal of the American Medical Informatics Association : JAMIA·Yen S LowAlexander Tropsha

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Software Mentioned

Office Access
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Molecular Access System
Molecular Operating Environment

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