A practical guide to understanding, using and including patient reported outcomes in clinical trials in ovarian cancer

Journal of Gynecologic Oncology
Michelle K WilsonMichael Friedlander

Abstract

Health related quality of life (HRQOL) is a key priority for patients with ovarian cancer as there is significant morbidity associated with the disease and the treatment. It is therefore essential to include measures of HRQOL and patient reported outcomes (PROs) in all clinical trials and ideally report them in the initial manuscript. The results of these analyses help interpret the primary trial endpoints which are typically progression free survival and overall survival from the perspective of the patients, but can also assist with regulatory approval of new drugs and inform future patients regarding the potential benefits and downsides of the treatment as well as help support clinical recommendations. Including PROs in clinical trials allows patient-defined clinical benefits to be assessed in parallel to traditional survival outcomes to provide a more holistic overview and aid in the interpretation of the trial results. Given the importance of these instruments in clinical trials, greater effort is required to improve the appropriate inclusion, quality of analyses and reporting of PROs. It is also essential that all clinicians understand the intricacies of the selection, implementation and interpretation of these measures of...Continue Reading

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Aug 26, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amit M OzaRobert L Coleman
Jun 8, 2021·Gynecologic Oncology Reports·Catherine N ZivanovLauren S Prescott

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