A practical review of prognostic correlations of molecular biomarkers in glioblastoma

Neurosurgical Focus
Michael KarsyRandy L Jensen

Abstract

Despite extensive efforts in research and therapeutics, achieving longer survival for patients with glioblastoma (GBM) remains a formidable challenge. Furthermore, because of rapid advances in the scientific understanding of GBM, communication with patients regarding the explanations and implications of genetic and molecular markers can be difficult. Understanding the important biomarkers that play a role in GBM pathogenesis may also help clinicians in educating patients about prognosis, potential clinical trials, and monitoring response to treatments. This article aims to provide an up-to-date review that can be discussed with patients regarding common molecular markers, namely O-6-methylguanine-DNA methyltransferase (MGMT), isocitrate dehydrogenase 1 and 2 (IDH1/2), p53, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), phosphatase and tensin homolog (PTEN), phosphoinositide 3-kinase (PI3K), and 1p/19q. The importance of the distinction between a prognostic and a predictive biomarker as well as clinical trials regarding these markers and their relevance to clinical practice are discussed.

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A J WongB Vogelstein
Feb 1, 1997·Journal of Neuropathology and Experimental Neurology·W BiernatH Ohgaki
Apr 17, 2001·Brain Pathology·M NakamuraH Ohgaki
Apr 10, 2002·Journal of Neuropathology and Experimental Neurology·Matthias C SchmidtAndreas von Deimling
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
May 19, 2005·Cancer Research·Jeremy N RichMike West
Oct 26, 2005·Neoplasia : an International Journal for Oncology Research·Silke WemmertSteffi Urbschat
Jan 16, 2007·Journal of Neuro-oncology·Emmanuelle CrinièreMarc Sanson
Jan 20, 2007·Acta Neuropathologica·Daisuke KitaHiroko Ohgaki
Sep 6, 2008·Science·D Williams ParsonsKenneth W Kinzler
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Oct 7, 2008·Cancer Biology & Therapy·Dimpy Koul
Jan 15, 2009·American Journal of Clinical Pathology·Yolanda RuanoBárbara Meléndez
Oct 29, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jörg FelsbergMichael C Sabel
Nov 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfgang WickMichael Weller
Apr 20, 2010·Cancer Cell·Houtan NoushmehrUNKNOWN Cancer Genome Atlas Research Network
Oct 5, 2010·Genes & Development·Tatsuya OzawaEric C Holland
Mar 29, 2011·Brain Tumor Pathology·Hiroko Ohgaki, Paul Kleihues
Jan 25, 2012·Current Cancer Drug Targets·T E TaylorW K Cavenee
May 15, 2012·The Lancet Oncology·Wolfgang WickUNKNOWN NOA-08 Study Group of Neuro-oncology Working Group (NOA) of German Cancer Society
Aug 30, 2012·Journal of Neuro-oncology·Matthias HoldhoffLuis A Diaz
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory CairncrossMinesh Mehta
Feb 1, 2013·Neuropathology and Applied Neurobiology·K H ClarkC Horbinski
Feb 23, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sandra H E Boots-SprengerPieter Wesseling
Apr 30, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Arshawn Sami, Michael Karsy
Jun 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bryant EnglandMichael Karsy
Jul 24, 2013·Journal of Neuro-oncology·Mohamad A SalkeniEl Mustapha Bahassi
Aug 7, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christian HartmannUNKNOWN German Glioma Network
Dec 4, 2013·Future Oncology·Daniel KrellChiara Bardella
Dec 7, 2013·Neuro-oncology·Jiaxin ZhaoHong Zhao
Jan 9, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Michael KarsyMeena Jhanwar-Uniyal

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Citations

Jun 5, 2016·Biochemistry. Biokhimii︠a︡·A A StavrovskayaE Yu Rybalkina
Mar 17, 2016·Stem Cells International·Seon-Jin YoonSeok-Gu Kang
Oct 16, 2015·International Journal of Molecular Medicine·Eva BlahovcovaJozef Hatok
Aug 4, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·R CerquaL Provinciali
Jan 19, 2016·Pathology, Research and Practice·Jun LiMeizuo Zhong
Aug 4, 2015·Neurosurgical Focus·Michael KarsyMark A Mahan
Mar 27, 2018·CNS Neuroscience & Therapeutics·Wen WangJi-Zong Zhao
Sep 26, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Alexandra Y TsidulkoElvira V Grigorieva
Jun 15, 2018·International Journal of Molecular Sciences·Ha S NguyenNinh Doan
Feb 13, 2018·World Journal of Surgical Oncology·Ivo TrogrlićAmina Kadrić Trogrlić
Sep 27, 2019·International Journal of Molecular Sciences·Francesco P CammarataGiorgio Russo
Sep 10, 2017·Brain Tumor Pathology·Lawrance K ChungIsaac Yang
Mar 9, 2017·Current Neurology and Neuroscience Reports·Michael KarsyHoward Colman
Nov 20, 2015·Neurosurgery·Benjamin M ZussmanJohnathan A Engh
Jul 15, 2020·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Judith M KampaHanna Bednarz
Jul 14, 2016·Journal of Neuro-oncology·Ki-Su ParkJeong-Hyun Hwang
Feb 25, 2017·Journal of Neuro-oncology·Kirsten Ludwig, Harley I Kornblum
Feb 17, 2018·Journal of Neuro-oncology·Alexander Perdomo-PantojaTalia Wegman-Ostrosky
Jan 13, 2018·Molecular Medicine Reports·Hai-Bo QiaoZhi-Ming Zhang
Dec 3, 2017·Journal of Neuro-oncology·Eric GoetheNaveen Pemmaraju
Nov 24, 2017·Journal of Neuro-oncology·Wen WangJizong Zhao
Jul 8, 2017·Journal of Neuro-oncology·Al-Wala AwadMark A Mahan
Dec 29, 2019·Scientific Reports·Matthew T CarrWilliam C Broaddus
Oct 12, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francesco AcerbiPaolo Ferroli
Jan 23, 2021·World Neurosurgery·Ravi S NunnaRichard W Byrne
May 3, 2019·Oncology Reviews·Abdul Aziz Mohamed YusoffSiti Muslihah Abd Radzak
Feb 16, 2021·Frontiers in Oncology·Shunnan GeLiang Wang

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