A prairie dog animal model of systemic orthopoxvirus disease using West African and Congo Basin strains of monkeypox virus

The Journal of General Virology
Christina L HutsonRussell L Regnery

Abstract

Multiple monkeypox virus (MPXV) animal models have been discussed in previous studies, but no small animal models, nor most non-human primate models, demonstrated the protracted asymptomatic incubation phase seen in systemic human orthopoxvirus illness. Herein, we characterize a black-tailed prairie dog (PD) (Cynomys ludovicianus) model of infection, via intranasal and intradermal exposures, with the two MPXV clades. Daily observations of the animals were made (food consumption, general symptoms, disease presentation), while weights and virus evaluations (ocular, nasal, oropharyngeal, faeces, blood) were obtained/made every third day. Generalized rash became apparent 9-12 days post-infection for all animals. Individual animals demonstrated a range of symptoms consistent with human monkeypox disease. Measurable viraemias and excretas were similar for both clade-representative strains and persisted until at least day 21. Greater morbidity was observed in Congo Basin strain-challenged animals and mortality was observed only in the Congo Basin strain-challenged animals. The PD model is valuable for the study of strain-dependent differences in MPXV. Additionally, the model closely mimics human systemic orthopoxvirus disease and may ...Continue Reading

References

Sep 1, 1988·International Journal of Epidemiology·P E FineH Dixon
Jul 1, 1985·The American Journal of Tropical Medicine and Hygiene·I AritaK Ruti
Aug 1, 1987·The Journal of Infectious Diseases·Z JezekM Mutombo
Jun 1, 2001·Emerging Infectious Diseases·Y J HutinJ J Esposito
Dec 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·G M ZauchaL Hensley
Mar 30, 2002·The New England Journal of Medicine·Joel G Breman, D A Henderson
May 1, 1997·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·P.T. MwanbalJ.J. Esposito
Jan 23, 2004·The New England Journal of Medicine·Kurt D ReedInger K Damon
Apr 23, 2004·The New England Journal of Medicine·Gregory D HuhnMark S Dworkin
Apr 28, 2004·Emerging Infectious Diseases·Jeannette GuarnerUNKNOWN Veterinary Monkeypox Virus Working Group
Sep 29, 2004·The Lancet Infectious Diseases·Mary G ReynoldsInger Damon
Oct 23, 2004·Emerging Infectious Diseases·Robert B TeshShu-Yuan Xiao
Apr 15, 2005·Emerging Infectious Diseases·Shu-Yuan XiaoRobert B Tesh
Sep 28, 2005·The Journal of General Virology·Anna M LikosInger K Damon
Nov 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory D HuhnMatthew J Kuehnert
May 30, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yu LiInger K Damon
Aug 31, 2006·The Journal of Infectious Diseases·Mary G ReynoldsInger K Damon
Jun 8, 2007·Emerging Infectious Diseases·Anne W RimoinHermann Meyer

❮ Previous
Next ❯

Citations

Jun 22, 2011·Virology Journal·Nadia F Gallardo-RomeroVictoria A Olson
Aug 12, 2009·PloS One·Jorge E OsorioTonie E Rocke
May 17, 2014·PLoS Pathogens·Dina AlzhanovaKlaus Früh
Sep 24, 2010·Future Microbiology·Clement A Meseda, Jerry P Weir
Oct 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea M McCollum, Inger K Damon
Oct 2, 2012·Veterinary Microbiology·Anselmo V RivettiZélia I P Lobato
Dec 21, 2011·Antiviral Research·Sharon E AltmannJoseph E Blaney
Jan 5, 2011·Immunological Reviews·Bernard Moss
May 7, 2015·Transboundary and Emerging Diseases·A A SergeevA N Sergeev
Jan 20, 2015·Transboundary and Emerging Diseases·Al A SergeevA N Sergeev
Oct 23, 2010·The Journal of General Virology·Aysegul Nalca, Donald K Nichols
Jun 20, 2012·Current Opinion in Virology·Mary G ReynoldsKevin L Karem
Oct 16, 2009·Veterinary Microbiology·Sandra EssbauerHermann Meyer
Oct 25, 2016·Archives of Virology·Lara Ambrosio Leal DutraGiliane de Souza Trindade
Aug 5, 2010·Veterinary Pathology·J L ChapmanJ W Raymond
Aug 23, 2017·PLoS Neglected Tropical Diseases·Elizabeth A FalendyszTonie E Rocke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.