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A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming

Stem Cells

Apr 1, 2013

Yun-Shen ChanHuck-Hui Ng

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Abstract

PRDM14 is an important determinant of the human embryonic stem cell (ESC) identity and works in concert with the core ESC regulators to activate pluripotency-associated genes. PRDM14 has been previously reported to exhibit repressive activity in mouse ESCs and primordial germ cells; and...read more

Mentioned in this Paper

Lysine
Hyperimmunoglobulin G1(A1) Syndrome
Transcription Initiation
Repressor Molecules
Genes, Developmental
ZEB1 gene
PRDM14 protein, human
Homeodomain Proteins
Histone H3
Transcription Repressor/Corepressor
4
78
Paper Details
References
    • References33
    • Citations26
    • References33
    • Citations26
  • A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming

    Stem Cells

    Apr 1, 2013

    Yun-Shen ChanHuck-Hui Ng

    PMID: 23280602

    DOI: 10.1002/stem.1307

    Abstract

    PRDM14 is an important determinant of the human embryonic stem cell (ESC) identity and works in concert with the core ESC regulators to activate pluripotency-associated genes. PRDM14 has been previously reported to exhibit repressive activity in mouse ESCs and primordial germ cells; and...read more

    Mentioned in this Paper

    Lysine
    Hyperimmunoglobulin G1(A1) Syndrome
    Transcription Initiation
    Repressor Molecules
    Genes, Developmental
    4
    78

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    Paper Details
    References
    • References33
    • Citations26
    • References33
    • Citations26
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