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A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming

Stem Cells

Jan 3, 2013

Yun-Shen ChanHuck-Hui Ng

Abstract

PRDM14 is an important determinant of the human embryonic stem cell (ESC) identity and works in concert with the core ESC regulators to activate pluripotency-associated genes. PRDM14 has been previously reported to exhibit repressive activity in mouse ESCs and primordial germ cells; and...read more

Mentioned in this Paper

ZEB1 protein, human
Transcription Repressor/Corepressor
Specimen Type - Fibroblasts
Pluripotent Stem Cells
Enhanced S-Cone Syndrome
ZEB1 gene
Human Induced Pluripotent Stem Cells
Transcription Initiation
PRDM14 protein, human
Plasma Protein Binding Capacity
4
79
Paper Details
References
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  • Citations28
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  • References33
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A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming

Stem Cells

Jan 3, 2013

Yun-Shen ChanHuck-Hui Ng

PMID: 23280602

DOI: 10.1002/stem.1307

Abstract

PRDM14 is an important determinant of the human embryonic stem cell (ESC) identity and works in concert with the core ESC regulators to activate pluripotency-associated genes. PRDM14 has been previously reported to exhibit repressive activity in mouse ESCs and primordial germ cells; and...read more

Mentioned in this Paper

ZEB1 protein, human
Transcription Repressor/Corepressor
Specimen Type - Fibroblasts
Pluripotent Stem Cells
Enhanced S-Cone Syndrome
ZEB1 gene
Human Induced Pluripotent Stem Cells
Transcription Initiation
PRDM14 protein, human
Plasma Protein Binding Capacity
4
79

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Induced Pluripotent Stem Cells

Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors, These cells have similar properties to those of embryonic stem cells (escs) but bypass the ethical concerns of embryo destruction and can be exploited for both research and clinical applications.Discover the latest research on iPSC here.

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Paper Details
References
  • References33
  • Citations28
1234
  • References33
  • Citations28
123
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