A pre-protective strategy for precise tumor targeting and efficient photodynamic therapy with a switchable DNA/upconversion nanocomposite

Chemical Science
Zhengze YuBo Tang

Abstract

Tumor-specific targeting based on folic acid (FA) is one of the most common and significant approaches in cancer therapy. However, the expression of folate receptors (FRs) in normal tissues will lead to unexpected targeting and unsatisfactory therapeutic effect. To address this issue, we develop a pre-protective strategy for precise tumor targeting and efficient photodynamic therapy (PDT) using a switchable DNA/upconversion nanocomposite, which can be triggered in the acidic tumor microenvironment. The DNA/upconversion nanocomposite is composed of polyacrylic acid (PAA) coated upconversion nanoparticles (UCNPs), the surface of which is modified using FA and chlorin e6 (Ce6) functionalized DNA sequences with different lengths. Initially, FA on the shorter DNA was protected by a longer DNA to prevent the bonding to FRs on normal cells. Once reaching the acidic tumor microenvironment, C base-rich longer DNA forms a C-quadruplex, resulting in the exposure of the FA groups and the bonding of FA and FRs on cancer cell membranes to achieve precise targeting. Simultaneously, the photosensitizer chlorin e6 (Ce6) gets close to the surface of UCNPs, enabling the excitation of Ce6 to generate singlet oxygen (1O2) under near infrared light ...Continue Reading

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Citations

Dec 1, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Yuanyuan YouTianfeng Chen
Apr 11, 2019·Chemical Communications : Chem Comm·Wei PanBo Tang
Oct 17, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cherie Ann Kruger, Heidi Abrahamse
Mar 19, 2019·Chemical Science·Shanyue GuanShuyun Zhou
Jan 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao JiaYu-Kui Zhang
Apr 21, 2021·Chemical Communications : Chem Comm·Zhengze YuBo Tang
Jun 27, 2019·Biomacromolecules·Roberto ZagamiAntonino Mazzaglia

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Methods Mentioned

BETA
FRET
transmission electron microscopy
Fluorescence
flow cytometry
xenograft

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