A pre-therapeutic coating for medical devices that prevents the attachment of Candida albicans

Annals of Clinical Microbiology and Antimicrobials
Diego Vargas-BlancoReeta P Rao

Abstract

Hospital acquired fungal infections are defined as "never events"-medical errors that should never have happened. Systemic Candida albicans infections results in 30-50% mortality rates. Typically, adhesion to abiotic medical devices and implants initiates such infections. Efficient adhesion initiates formation of aggressive biofilms that are difficult to treat. Therefore, inhibitors of adhesion are important for drug development and likely to have a broad spectrum efficacy against many fungal pathogens. In this study we further the development of a small molecule, Filastatin, capable of preventing C. albicans adhesion. We explored the potential of Filastatin as a pre-therapeutic coating of a diverse range of biomaterials. Filastatin was applied on various biomaterials, specifically bioactive glass (cochlear implants, subcutaneous drug delivery devices and prosthetics); silicone (catheters and other implanted devices) and dental resin (dentures and dental implants). Adhesion to biomaterials was evaluated by direct visualization of wild type C. albicans or a non-adherent mutant edt1 -/- that were stained or fluorescently tagged. Strains grown overnight at 30 °C were harvested, allowed to attach to surfaces for 4 h and washed prio...Continue Reading

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Citations

Sep 27, 2019·Medical Microbiology and Immunology·Moses MadendeCarolina H Pohl
Nov 9, 2018·Journal of Fungi·Asmaa B ElkabtiReeta P Rao
Sep 12, 2018·Medical Mycology·Judith Díaz-GarcíaPilar Escribano
Oct 13, 2020·Frontiers in Microbiology·Noel Vera-González, Anita Shukla
Jun 23, 2020·Colloids and Surfaces. B, Biointerfaces·Thomas J DaubenKlaus D Jandt
Apr 15, 2020·Acta Biomaterialia·Fei TanMohamed Al-Rubeai
May 23, 2020·Chemical Reviews·Yunjin LeeLeah E Cowen
Jun 26, 2021·Folia Microbiologica·Ravishankar SrikanthParamasivam Nithyanand

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Methods Mentioned

BETA
cochlear implants
atomic force microscopy
AFM
force
biosensing
force measurement
electron impedance spectroscopy
Quartz Crystal Microbalance

Software Mentioned

ImageJ

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