A precise polyrotaxane synthesizer

Science
Yunyan QiuJ Fraser Stoddart

Abstract

Mechanically interlocked molecules are likely candidates for the design and synthesis of artificial molecular machines. Although polyrotaxanes have already found niche applications in exotic materials with specialized mechanical properties, efficient synthetic protocols to produce them with precise numbers of rings encircling their polymer dumbbells are still lacking. We report the assembly line-like emergence of poly[n]rotaxanes with increasingly higher energies by harnessing artificial molecular pumps to deliver rings in pairs by cyclical redox-driven processes. This programmable strategy leads to the precise incorporation of two, four, six, eight, and 10 rings carrying 8+, 16+, 24+, 32+, and 40+ charges, respectively, onto hexacationic polymer dumbbells. This strategy depends precisely on the number of redox cycles applied chemically or electrochemically, in both stepwise and one-pot manners.

References

Oct 7, 1998·European Biophysics Journal : EBJ·R D Astumian, I Derényi
Feb 19, 2002·Chemical Reviews·Françisco M. Raymo, J. Fraser Stoddart
Mar 30, 2002·Science·Jean-Marie Lehn
Oct 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jishan WuJ Fraser Stoddart
Dec 17, 2008·Science·Alexander B C DeutmanAlan E Rowan
Aug 13, 2009·Chemical Reviews·Zhenbin Niu, Harry W Gibson
Sep 10, 2009·Chemical Reviews·Akira HaradaYoshinori Takashima
Jul 21, 2010·Nanoscale·Karla K CotíJ Fraser Stoddart
Mar 2, 2011·Applied Microbiology and Biotechnology·Jia Jing LiJun Li
Oct 26, 2011·Journal of the American Chemical Society·Nebojša MomčilovićRobert H Grubbs
Feb 7, 2012·Journal of the American Chemical Society·Matthew E BelowichJ Fraser Stoddart
Oct 17, 2013·The Journal of Organic Chemistry·Jonathan C BarnesJ Fraser Stoddart
Aug 26, 2014·Journal of the American Chemical Society·Songsu KangMichael F Mayer
Nov 25, 2014·Nature Nanotechnology·Giulio RagazzonAlberto Credi
May 20, 2015·Nature Nanotechnology·Chuyang ChengJ Fraser Stoddart
Sep 9, 2015·Chemical Reviews·Sundus Erbas-CakmakAlina L Nussbaumer
Oct 5, 2016·Journal of the American Chemical Society·James E M LewisStephen M Goldup
Mar 25, 2017·Chemical Society Reviews·Cristian PezzatoR Dean Astumian
Oct 6, 2017·ACS Central Science·Yuping WangJ Fraser Stoddart
Oct 21, 2017·Science·Sundus Erbas-CakmakMiriam R Wilson
Dec 2, 2017·Science·Qiong WuStuart J Rowan
May 19, 2018·Angewandte Chemie·Cristian PezzatoJ Fraser Stoddart
Sep 19, 2018·Nature Nanotechnology·Giulio Ragazzon, Leonard J Prins
Aug 17, 2019·Chemical Society Reviews·Sofía Mena-Hernando, Emilio M Pérez
Oct 18, 2019·Journal of the American Chemical Society·Yunyan QiuJ Fraser Stoddart
Jan 23, 2020·The Journal of Organic Chemistry·Milo D CornelissenJan H van Maarseveen

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Citations

Aug 26, 2020·Organic & Biomolecular Chemistry·Nadia Hoyas Pérez, James E M Lewis
Dec 29, 2020·Journal of the American Chemical Society·Yu-Dong YangHan-Yuan Gong
Dec 29, 2020·Angewandte Chemie·Xue YangDavid Bardelang
Feb 25, 2021·Chemical Communications : Chem Comm·Ying-Ying ZhangWeibin Yu
Mar 26, 2021·Journal of the American Chemical Society·Javier EchavarrenChong Tian
Mar 12, 2021·Angewandte Chemie·Krishnendu DasLeonard J Prins
Apr 9, 2021·Journal of the American Chemical Society·Yuanning FengJ Fraser Stoddart
Apr 30, 2021·Journal of the American Chemical Society·Massimiliano CurcioAlberto Credi
May 12, 2021·Nature Communications·Jiabin YaoCheng Yang
May 25, 2021·Journal of the American Chemical Society·Yang JiaoJ Fraser Stoddart
May 28, 2021·Journal of the American Chemical Society·Hongliang ChenJ Fraser Stoddart
May 6, 2021·Chemistry : a European Journal·Stefano CorraAlberto Credi
Jun 25, 2021·Nature·Shuntaro AmanoDavid A Leigh
Jul 10, 2021·Organic Letters·Ting-Hsuan ChiangSheng-Hsien Chiu
Jul 21, 2021·Journal of the American Chemical Society·Martina CantonAlberto Credi
Jun 11, 2021·Angewandte Chemie·Daisuke ShimoyamaFrieder Jäkle
Oct 29, 2020·Journal of the American Chemical Society·Kerstin Grill, Henry Dube
Dec 22, 2020·Journal of the American Chemical Society·Ommid AnamimoghadamJ Fraser Stoddart
Aug 14, 2020·Journal of the American Chemical Society·Qing-Hui GuoJ Fraser Stoddart
Jan 7, 2021·Journal of the American Chemical Society·Li ShaoJerry L Atwood
Oct 15, 2021·Nature·Wenjing MengHiroshi Sato
Nov 25, 2021·Chemical Communications : Chem Comm·Yidan ZhouLihua Yuan
Dec 25, 2021·Physical Chemistry Chemical Physics : PCCP·Haohao FuWensheng Cai
Dec 8, 2021·Nanotechnology·Eberechukwu Victoria AmadiChris Papadopoulos

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